Therapeutic Applications of Mesenchymal Stem Cells to Repair Kidney Injury

Hiroshi Asanuma, Daniel R. Meldrum, Kirstan K. Meldrum

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Purpose: The potential use of stem cells for acute and chronic renal injury is under intensive investigation. We summarized the current literature on the potential therapeutic role of mesenchymal stem cells for kidney injury. Materials and Methods: We reviewed the pertinent literature on mesenchymal stem cell therapy for acute and chronic renal injury. Results: Experimental evidence suggests that administering exogenous mesenchymal stem cells during acute and chronic kidney injury may improve functional and structural recovery of the tubular, glomerular and interstitial kidney compartments. Several studies point to a paracrine and/or endocrine mechanism of action rather than to direct repopulation of cells in the injured nephron. Multiple questions remain unanswered regarding the protective action of mesenchymal stem cells during renal injury, including signals that regulate stem cell homing to injured tissue, factors regulating paracrine and/or endocrine activity of exogenous mesenchymal stem cells and particularly the long-term behavior of administered stem cells in vivo. Conclusions: Many questions remain unanswered but mesenchymal stem cell based therapy is a promising new strategy for acute and chronic kidney disease.

Original languageEnglish
Pages (from-to)26-33
Number of pages8
JournalJournal of Urology
Volume184
Issue number1
DOIs
Publication statusPublished - 2010 Jul
Externally publishedYes

Fingerprint

Mesenchymal Stromal Cells
Kidney
Wounds and Injuries
Acute Kidney Injury
Stem Cells
Cell- and Tissue-Based Therapy
Therapeutics
Nephrons
Thromboplastin
Chronic Renal Insufficiency

Keywords

  • kidney
  • kidney diseases
  • kidney failure
  • mesenchymal stem cells
  • paracrine communication

ASJC Scopus subject areas

  • Urology

Cite this

Therapeutic Applications of Mesenchymal Stem Cells to Repair Kidney Injury. / Asanuma, Hiroshi; Meldrum, Daniel R.; Meldrum, Kirstan K.

In: Journal of Urology, Vol. 184, No. 1, 07.2010, p. 26-33.

Research output: Contribution to journalArticle

Asanuma, Hiroshi ; Meldrum, Daniel R. ; Meldrum, Kirstan K. / Therapeutic Applications of Mesenchymal Stem Cells to Repair Kidney Injury. In: Journal of Urology. 2010 ; Vol. 184, No. 1. pp. 26-33.
@article{98ba1a3b1c0a48b583a456e3042b5b0e,
title = "Therapeutic Applications of Mesenchymal Stem Cells to Repair Kidney Injury",
abstract = "Purpose: The potential use of stem cells for acute and chronic renal injury is under intensive investigation. We summarized the current literature on the potential therapeutic role of mesenchymal stem cells for kidney injury. Materials and Methods: We reviewed the pertinent literature on mesenchymal stem cell therapy for acute and chronic renal injury. Results: Experimental evidence suggests that administering exogenous mesenchymal stem cells during acute and chronic kidney injury may improve functional and structural recovery of the tubular, glomerular and interstitial kidney compartments. Several studies point to a paracrine and/or endocrine mechanism of action rather than to direct repopulation of cells in the injured nephron. Multiple questions remain unanswered regarding the protective action of mesenchymal stem cells during renal injury, including signals that regulate stem cell homing to injured tissue, factors regulating paracrine and/or endocrine activity of exogenous mesenchymal stem cells and particularly the long-term behavior of administered stem cells in vivo. Conclusions: Many questions remain unanswered but mesenchymal stem cell based therapy is a promising new strategy for acute and chronic kidney disease.",
keywords = "kidney, kidney diseases, kidney failure, mesenchymal stem cells, paracrine communication",
author = "Hiroshi Asanuma and Meldrum, {Daniel R.} and Meldrum, {Kirstan K.}",
year = "2010",
month = "7",
doi = "10.1016/j.juro.2010.03.050",
language = "English",
volume = "184",
pages = "26--33",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Therapeutic Applications of Mesenchymal Stem Cells to Repair Kidney Injury

AU - Asanuma, Hiroshi

AU - Meldrum, Daniel R.

AU - Meldrum, Kirstan K.

PY - 2010/7

Y1 - 2010/7

N2 - Purpose: The potential use of stem cells for acute and chronic renal injury is under intensive investigation. We summarized the current literature on the potential therapeutic role of mesenchymal stem cells for kidney injury. Materials and Methods: We reviewed the pertinent literature on mesenchymal stem cell therapy for acute and chronic renal injury. Results: Experimental evidence suggests that administering exogenous mesenchymal stem cells during acute and chronic kidney injury may improve functional and structural recovery of the tubular, glomerular and interstitial kidney compartments. Several studies point to a paracrine and/or endocrine mechanism of action rather than to direct repopulation of cells in the injured nephron. Multiple questions remain unanswered regarding the protective action of mesenchymal stem cells during renal injury, including signals that regulate stem cell homing to injured tissue, factors regulating paracrine and/or endocrine activity of exogenous mesenchymal stem cells and particularly the long-term behavior of administered stem cells in vivo. Conclusions: Many questions remain unanswered but mesenchymal stem cell based therapy is a promising new strategy for acute and chronic kidney disease.

AB - Purpose: The potential use of stem cells for acute and chronic renal injury is under intensive investigation. We summarized the current literature on the potential therapeutic role of mesenchymal stem cells for kidney injury. Materials and Methods: We reviewed the pertinent literature on mesenchymal stem cell therapy for acute and chronic renal injury. Results: Experimental evidence suggests that administering exogenous mesenchymal stem cells during acute and chronic kidney injury may improve functional and structural recovery of the tubular, glomerular and interstitial kidney compartments. Several studies point to a paracrine and/or endocrine mechanism of action rather than to direct repopulation of cells in the injured nephron. Multiple questions remain unanswered regarding the protective action of mesenchymal stem cells during renal injury, including signals that regulate stem cell homing to injured tissue, factors regulating paracrine and/or endocrine activity of exogenous mesenchymal stem cells and particularly the long-term behavior of administered stem cells in vivo. Conclusions: Many questions remain unanswered but mesenchymal stem cell based therapy is a promising new strategy for acute and chronic kidney disease.

KW - kidney

KW - kidney diseases

KW - kidney failure

KW - mesenchymal stem cells

KW - paracrine communication

UR - http://www.scopus.com/inward/record.url?scp=77953120977&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953120977&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2010.03.050

DO - 10.1016/j.juro.2010.03.050

M3 - Article

C2 - 20478602

AN - SCOPUS:77953120977

VL - 184

SP - 26

EP - 33

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 1

ER -