Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway.

Mamoru Watanabe, Motomi Yamazaki, Ryuichi Okamoto, Shinya Ohoka, Akihiro Araki, Tetsuya Nakamura, Takanori Kanai

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Inflammatory bowel disease is thought to result from inappropriate activation of mucosal immune responses. Intestinal epithelial cells produce interleukin (IL)-7 that serves as a regulatory factor for IL-7 receptor (IL-7R)(+) mucosal lymphocytes. The pivotal role of mucosal IL-7/IL-7R dependent signals in the activation of mucosal immune responses that lead to the development of chronic intestinal inflammation are demonstrated. Therapeutic approaches targeting IL-7/IL-7R signal pathway may be feasible in the treatment of inflammatory bowel disease.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalCurrent drug targets. Inflammation and allergy
Volume2
Issue number2
Publication statusPublished - 2003 Jun
Externally publishedYes

Fingerprint

Interleukin-7
Interleukins
Signal Transduction
Mucosal Immunity
Inflammation
Inflammatory Bowel Diseases
Interleukin-7 Receptors
Therapeutics
Epithelial Cells
Lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pharmacology
  • Immunology

Cite this

Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway. / Watanabe, Mamoru; Yamazaki, Motomi; Okamoto, Ryuichi; Ohoka, Shinya; Araki, Akihiro; Nakamura, Tetsuya; Kanai, Takanori.

In: Current drug targets. Inflammation and allergy, Vol. 2, No. 2, 06.2003, p. 119-123.

Research output: Contribution to journalArticle

Watanabe, Mamoru ; Yamazaki, Motomi ; Okamoto, Ryuichi ; Ohoka, Shinya ; Araki, Akihiro ; Nakamura, Tetsuya ; Kanai, Takanori. / Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway. In: Current drug targets. Inflammation and allergy. 2003 ; Vol. 2, No. 2. pp. 119-123.
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