Therapeutic strategies for functional dyspepsia and the introduction of the Rome III classification

Hidekazu Suzuki, Toshihiro Nishizawa, Toshifumi Hibi

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

Although placebo response rates in clinical trials for functional dyspepsia (FD) are more than 30%, a recent meta-analysis based on randomized controlled trials (RCTs) showed that antisecretory drugs were more or less superior to placebos. On the other hand, large-scale RCTs on the efficacy of treatment with prokinetics on FD are still needed. Indications for antibiotic eradication therapy for Helicobacter pylori-positive FD are still controversial, but there seems to be a small but significant therapeutic gain achieved with H. pylori eradication. Since preprandial and postprandial symptomatic disturbances are very important targets for FD treatment, ghrelin, a novel appetite-promoting gastrointestinal peptide that also promotes gastric motility or basal acid secretion can be expected to be a therapeutic target. In the recently published Rome III classification, FD is redefined for patients with symptoms thought to originate from the gastroduodenal region, specifically epigastric pain or burning, postprandial fullness, or early satiation, and it is divided into the subcategories postprandial distress syndrome and epigastric pain syndrome. These new criteria are of value in clinical practice, for epidemiological, pathophysiological, and clinical research, and for the development of new therapeutic strategies.

Original languageEnglish
Pages (from-to)513-523
Number of pages11
JournalJournal of gastroenterology
Volume41
Issue number6
DOIs
Publication statusPublished - 2006 Jun 1

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Keywords

  • Epigastric pain syndrome (EPS)
  • Ghrelin
  • Placebo
  • Postprandial distress syndrome (PDS)
  • Prokinetics

ASJC Scopus subject areas

  • Gastroenterology

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