Therapeutic value of lymph node dissection during hepatectomy in patients with intrahepatic cholangiocellular carcinoma with negative lymph node involvement

Kazuaki Shimada, Tsuyoshi Sano, Satoshi Nara, Minoru Esaki, Yoshihiro Sakamoto, Tomoo Kosuge, Hidenori Ojima

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Abstract

Background: Routine and radical lymph node dissection is a clinical concern for improving the surgical outcome in patients with intrahepatic cholangiocarcinoma (ICC). The therapeutic value of the procedure during hepatectomy has, however, not been evaluated. Methods: Between January 1990 and December 2004, 104 patients with ICC undergoing macroscopic curative resections were investigated retrospectively with special reference to lymph node status. The role of lymph node dissection was evaluated according to macroscopic type: mass-forming (MF) type (n = 68) and MF plus periductal infiltration (PI) type (n = 36) of ICC. Results: Lymph node involvement and intrahepatic metastases were an independent, unfavorable prognostic factor in the MF type of ICC. Negative lymph node involvement provided a favorable survival rate in the 41 patients without intrahepatic metastases (P < .0001). Among the 29 patients without lymph node involvement and intrahepatic metastases, there was no difference according to the use of lymph node dissection (P = .8071). Also, no difference was seen with lymph node involvement in the 24 patients with the MF plus PI type of ICC who had no intrahepatic metastases (P = .6620). Conclusion: For purpose of diagnostic staging and exclusion of positive regional lymph nodes, lymph node dissections might be useful in patients with the MF type and the MF plus PI type of ICC; however, routine use of lymph node dissection in patients with the MF type of ICC is not recommended, because no difference in survival was observed in the patients with negative lymph node metastases, irrespective of the use of lymph node dissection.

Original languageEnglish
Pages (from-to)411-416
Number of pages6
JournalSurgery
Volume145
Issue number4
DOIs
Publication statusPublished - 2009 Apr
Externally publishedYes

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Cholangiocarcinoma
Hepatectomy
Lymph Node Excision
Lymph Nodes
Neoplasm Metastasis
Therapeutics
Survival Rate
Survival

ASJC Scopus subject areas

  • Surgery

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Therapeutic value of lymph node dissection during hepatectomy in patients with intrahepatic cholangiocellular carcinoma with negative lymph node involvement. / Shimada, Kazuaki; Sano, Tsuyoshi; Nara, Satoshi; Esaki, Minoru; Sakamoto, Yoshihiro; Kosuge, Tomoo; Ojima, Hidenori.

In: Surgery, Vol. 145, No. 4, 04.2009, p. 411-416.

Research output: Contribution to journalArticle

Shimada, Kazuaki ; Sano, Tsuyoshi ; Nara, Satoshi ; Esaki, Minoru ; Sakamoto, Yoshihiro ; Kosuge, Tomoo ; Ojima, Hidenori. / Therapeutic value of lymph node dissection during hepatectomy in patients with intrahepatic cholangiocellular carcinoma with negative lymph node involvement. In: Surgery. 2009 ; Vol. 145, No. 4. pp. 411-416.
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AU - Sakamoto, Yoshihiro

AU - Kosuge, Tomoo

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N2 - Background: Routine and radical lymph node dissection is a clinical concern for improving the surgical outcome in patients with intrahepatic cholangiocarcinoma (ICC). The therapeutic value of the procedure during hepatectomy has, however, not been evaluated. Methods: Between January 1990 and December 2004, 104 patients with ICC undergoing macroscopic curative resections were investigated retrospectively with special reference to lymph node status. The role of lymph node dissection was evaluated according to macroscopic type: mass-forming (MF) type (n = 68) and MF plus periductal infiltration (PI) type (n = 36) of ICC. Results: Lymph node involvement and intrahepatic metastases were an independent, unfavorable prognostic factor in the MF type of ICC. Negative lymph node involvement provided a favorable survival rate in the 41 patients without intrahepatic metastases (P < .0001). Among the 29 patients without lymph node involvement and intrahepatic metastases, there was no difference according to the use of lymph node dissection (P = .8071). Also, no difference was seen with lymph node involvement in the 24 patients with the MF plus PI type of ICC who had no intrahepatic metastases (P = .6620). Conclusion: For purpose of diagnostic staging and exclusion of positive regional lymph nodes, lymph node dissections might be useful in patients with the MF type and the MF plus PI type of ICC; however, routine use of lymph node dissection in patients with the MF type of ICC is not recommended, because no difference in survival was observed in the patients with negative lymph node metastases, irrespective of the use of lymph node dissection.

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