Therapy-related acute myeloid leukemia after the long-term administration of low-dose etoposide for chronic-type adult T-cell leukemia-lymphoma

A case report and literature review

Naoki Shimada, Nobuhiro Ohno, Ryuji Tanosaki, Shigeo Fuji, Yuhko Suzuki, Koichiro Yuji, Kaoru Uchimaru, Arinobu Tojo

Research output: Contribution to journalArticle

Abstract

A 61-year-old woman with chronic-type adult T-cell leukemia-lymphoma (ATL) had been taking low-dose oral etoposide for progressive lymphocytosis. After taking this for 3.5 years, she was diagnosed with therapy-related acute myeloid leukemia (t-AML), with a chromosomal translocation of t (6:11) (q27; q23). She thus received remission induction therapy, consolidation therapy, and allogeneic hematopoietic stem cell transplantation. Although both t-AML and ATL were in remissive states, she died of a therapy-related infection within 1 year. We reviewed 12 reported cases of AML complicating ATL to better characterize this unusual disease. We should therefore include t-AML in the differential diagnosis when administering low-dose etoposide for ATL over a long period of time.

Original languageEnglish
Pages (from-to)1879-1884
Number of pages6
JournalInternal Medicine
Volume56
Issue number14
DOIs
Publication statusPublished - 2017
Externally publishedYes

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T-Cell Prolymphocytic Leukemia
Adult T Cell Leukemia Lymphoma
Etoposide
Acute Myeloid Leukemia
Therapeutics
Remission Induction
Lymphocytosis
Genetic Translocation
Hematopoietic Stem Cell Transplantation
Differential Diagnosis
Infection

Keywords

  • Allogeneic hematopoietic stem cell transplantation (allo-HSCT)
  • ATL
  • HTLV-1
  • t-AML

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Therapy-related acute myeloid leukemia after the long-term administration of low-dose etoposide for chronic-type adult T-cell leukemia-lymphoma : A case report and literature review. / Shimada, Naoki; Ohno, Nobuhiro; Tanosaki, Ryuji; Fuji, Shigeo; Suzuki, Yuhko; Yuji, Koichiro; Uchimaru, Kaoru; Tojo, Arinobu.

In: Internal Medicine, Vol. 56, No. 14, 2017, p. 1879-1884.

Research output: Contribution to journalArticle

Shimada, Naoki ; Ohno, Nobuhiro ; Tanosaki, Ryuji ; Fuji, Shigeo ; Suzuki, Yuhko ; Yuji, Koichiro ; Uchimaru, Kaoru ; Tojo, Arinobu. / Therapy-related acute myeloid leukemia after the long-term administration of low-dose etoposide for chronic-type adult T-cell leukemia-lymphoma : A case report and literature review. In: Internal Medicine. 2017 ; Vol. 56, No. 14. pp. 1879-1884.
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