Abstract
Background: Accumulation of data regarding therapy-related leukemia (TRL) or myelodysplastic syndrome (t-MDS) is critical for assessing the risk of developing such diseases and for subsequent decision-making processes for better treatment. Methods: We evaluated the clinical characteristics of patients with TRLVt-MDS diagnosed at the National Cancer Center Hospital between January 1989 and September 1997. This report is concerned with those patients who initially had been treated with chemotherapeutic agents for breast cancer. Results: Thirteen patients (median age, 55 years) developed TRL (n = 4) or t-MDS (n = 9). The median interval between the development of TRL/t-MDS and initial treatment was 94 months (range 23-190 months). For the primary therapy, all patients had received intense and prolonged treatment with cyclophosphamide (CPA) and/or anthracyclines including doxorubicin (DOX), with a median cumulative dose of 55 g/body (range 16.4-288.5 g) for CPA and 480 mg/m2 (range 395-625.5 mg/m2) for DOX. Seven patients were subsequently treated by chemotherapy and one received an allogeneic bone marrow transplantation. Conclusions: Clinicians must remain alert to the risks associated with unproven medical practices which include long-term administration of alkylating agents. Selected patients with TRL/t-MDS may respond to intense salvage combination chemotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 28-32 |
| Number of pages | 5 |
| Journal | Japanese Journal of Clinical Oncology |
| Volume | 29 |
| Issue number | 1 |
| Publication status | Published - 1999 Jan |
| Externally published | Yes |
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Keywords
- Breast cancer
- Cyclophosphamide
- Myelodysplastic syndrome
- Therapy-related leukemia
ASJC Scopus subject areas
- Oncology
Cite this
Therapy-related leukemia and myelodysplastic syndrome in breast cancer patients treated with cyclophosphamide or anthracyclines. / Ando, Masashi; Narabayashi, Masaru; Watanabe, Toru; Kamiya, Yoshikazu; Togitani, Kazuto; Tanosaki, Ryuji; Takenaka, Takeaki; Tobinai, Kensei; Adachi, Isamu.
In: Japanese Journal of Clinical Oncology, Vol. 29, No. 1, 01.1999, p. 28-32.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Therapy-related leukemia and myelodysplastic syndrome in breast cancer patients treated with cyclophosphamide or anthracyclines
AU - Ando, Masashi
AU - Narabayashi, Masaru
AU - Watanabe, Toru
AU - Kamiya, Yoshikazu
AU - Togitani, Kazuto
AU - Tanosaki, Ryuji
AU - Takenaka, Takeaki
AU - Tobinai, Kensei
AU - Adachi, Isamu
PY - 1999/1
Y1 - 1999/1
N2 - Background: Accumulation of data regarding therapy-related leukemia (TRL) or myelodysplastic syndrome (t-MDS) is critical for assessing the risk of developing such diseases and for subsequent decision-making processes for better treatment. Methods: We evaluated the clinical characteristics of patients with TRLVt-MDS diagnosed at the National Cancer Center Hospital between January 1989 and September 1997. This report is concerned with those patients who initially had been treated with chemotherapeutic agents for breast cancer. Results: Thirteen patients (median age, 55 years) developed TRL (n = 4) or t-MDS (n = 9). The median interval between the development of TRL/t-MDS and initial treatment was 94 months (range 23-190 months). For the primary therapy, all patients had received intense and prolonged treatment with cyclophosphamide (CPA) and/or anthracyclines including doxorubicin (DOX), with a median cumulative dose of 55 g/body (range 16.4-288.5 g) for CPA and 480 mg/m2 (range 395-625.5 mg/m2) for DOX. Seven patients were subsequently treated by chemotherapy and one received an allogeneic bone marrow transplantation. Conclusions: Clinicians must remain alert to the risks associated with unproven medical practices which include long-term administration of alkylating agents. Selected patients with TRL/t-MDS may respond to intense salvage combination chemotherapy.
AB - Background: Accumulation of data regarding therapy-related leukemia (TRL) or myelodysplastic syndrome (t-MDS) is critical for assessing the risk of developing such diseases and for subsequent decision-making processes for better treatment. Methods: We evaluated the clinical characteristics of patients with TRLVt-MDS diagnosed at the National Cancer Center Hospital between January 1989 and September 1997. This report is concerned with those patients who initially had been treated with chemotherapeutic agents for breast cancer. Results: Thirteen patients (median age, 55 years) developed TRL (n = 4) or t-MDS (n = 9). The median interval between the development of TRL/t-MDS and initial treatment was 94 months (range 23-190 months). For the primary therapy, all patients had received intense and prolonged treatment with cyclophosphamide (CPA) and/or anthracyclines including doxorubicin (DOX), with a median cumulative dose of 55 g/body (range 16.4-288.5 g) for CPA and 480 mg/m2 (range 395-625.5 mg/m2) for DOX. Seven patients were subsequently treated by chemotherapy and one received an allogeneic bone marrow transplantation. Conclusions: Clinicians must remain alert to the risks associated with unproven medical practices which include long-term administration of alkylating agents. Selected patients with TRL/t-MDS may respond to intense salvage combination chemotherapy.
KW - Breast cancer
KW - Cyclophosphamide
KW - Myelodysplastic syndrome
KW - Therapy-related leukemia
UR - http://www.scopus.com/inward/record.url?scp=0032603981&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032603981&partnerID=8YFLogxK
M3 - Article
C2 - 10073148
AN - SCOPUS:0032603981
VL - 29
SP - 28
EP - 32
JO - Japanese Journal of Clinical Oncology
JF - Japanese Journal of Clinical Oncology
SN - 0368-2811
IS - 1
ER -