Therapy-related leukemia and myelodysplastic syndrome in breast cancer patients treated with cyclophosphamide or anthracyclines

Masashi Ando, Masaru Narabayashi, Toru Watanabe, Yoshikazu Kamiya, Kazuto Togitani, Ryuji Tanosaki, Takeaki Takenaka, Kensei Tobinai, Isamu Adachi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Accumulation of data regarding therapy-related leukemia (TRL) or myelodysplastic syndrome (t-MDS) is critical for assessing the risk of developing such diseases and for subsequent decision-making processes for better treatment. Methods: We evaluated the clinical characteristics of patients with TRLVt-MDS diagnosed at the National Cancer Center Hospital between January 1989 and September 1997. This report is concerned with those patients who initially had been treated with chemotherapeutic agents for breast cancer. Results: Thirteen patients (median age, 55 years) developed TRL (n = 4) or t-MDS (n = 9). The median interval between the development of TRL/t-MDS and initial treatment was 94 months (range 23-190 months). For the primary therapy, all patients had received intense and prolonged treatment with cyclophosphamide (CPA) and/or anthracyclines including doxorubicin (DOX), with a median cumulative dose of 55 g/body (range 16.4-288.5 g) for CPA and 480 mg/m2 (range 395-625.5 mg/m2) for DOX. Seven patients were subsequently treated by chemotherapy and one received an allogeneic bone marrow transplantation. Conclusions: Clinicians must remain alert to the risks associated with unproven medical practices which include long-term administration of alkylating agents. Selected patients with TRL/t-MDS may respond to intense salvage combination chemotherapy.

Original languageEnglish
Pages (from-to)28-32
Number of pages5
JournalJapanese journal of clinical oncology
Volume29
Issue number1
DOIs
Publication statusPublished - 1999 Jan
Externally publishedYes

Keywords

  • Breast cancer
  • Cyclophosphamide
  • Myelodysplastic syndrome
  • Therapy-related leukemia

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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