Thermo-responsive protein adsorbing materials for purifying pharmaceutical protein on exposed charging surface

Kenichi Nagase; Simuck F. Yuk; Jun Kobayashi; Akihiko Kikuchi; Yoshikatsu Akiyama; Hideko Kanazawa; Teruo Okano

doi:10.1039/c0jm03453c

Thermo-responsive protein adsorbing materials for purifying pharmaceutical protein on exposed charging surface

Kenichi Nagase, Simuck F. Yuk, Jun Kobayashi, Akihiko Kikuchi, Yoshikatsu Akiyama, Hideko Kanazawa, Teruo Okano

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Thermo-responsive anionic terpolymer brushes with high selectivity for proteins were prepared though surface-initiated ATRP. Utilizing these terpolymer brushes, pure lysozyme was successfully separated from egg-white. Thus, the prepared thermo-responsive terpolymer brush is an effective separation tool for the pharmaceutical and biotechnological industries that produce valuable proteins.

Original language	English
Pages (from-to)	2590-2593
Number of pages	4
Journal	Journal of Materials Chemistry
Volume	21
Issue number	8
DOIs	https://doi.org/10.1039/c0jm03453c
Publication status	Published - 2011 Feb 28
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)
Materials Chemistry

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10.1039/c0jm03453c

Cite this

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abstract = "Thermo-responsive anionic terpolymer brushes with high selectivity for proteins were prepared though surface-initiated ATRP. Utilizing these terpolymer brushes, pure lysozyme was successfully separated from egg-white. Thus, the prepared thermo-responsive terpolymer brush is an effective separation tool for the pharmaceutical and biotechnological industries that produce valuable proteins.",

author = "Kenichi Nagase and Yuk, {Simuck F.} and Jun Kobayashi and Akihiko Kikuchi and Yoshikatsu Akiyama and Hideko Kanazawa and Teruo Okano",

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AU - Nagase, Kenichi

AU - Yuk, Simuck F.

AU - Kobayashi, Jun

AU - Kikuchi, Akihiko

AU - Akiyama, Yoshikatsu

AU - Kanazawa, Hideko

AU - Okano, Teruo

PY - 2011/2/28

Y1 - 2011/2/28

N2 - Thermo-responsive anionic terpolymer brushes with high selectivity for proteins were prepared though surface-initiated ATRP. Utilizing these terpolymer brushes, pure lysozyme was successfully separated from egg-white. Thus, the prepared thermo-responsive terpolymer brush is an effective separation tool for the pharmaceutical and biotechnological industries that produce valuable proteins.

AB - Thermo-responsive anionic terpolymer brushes with high selectivity for proteins were prepared though surface-initiated ATRP. Utilizing these terpolymer brushes, pure lysozyme was successfully separated from egg-white. Thus, the prepared thermo-responsive terpolymer brush is an effective separation tool for the pharmaceutical and biotechnological industries that produce valuable proteins.

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Thermo-responsive protein adsorbing materials for purifying pharmaceutical protein on exposed charging surface

Abstract

ASJC Scopus subject areas

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