Thermo-responsive protein adsorbing materials for purifying pharmaceutical protein on exposed charging surface

Kenichi Nagase, Simuck F. Yuk, Jun Kobayashi, Akihiko Kikuchi, Yoshikatsu Akiyama, Hideko Kanazawa, Teruo Okano

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Thermo-responsive anionic terpolymer brushes with high selectivity for proteins were prepared though surface-initiated ATRP. Utilizing these terpolymer brushes, pure lysozyme was successfully separated from egg-white. Thus, the prepared thermo-responsive terpolymer brush is an effective separation tool for the pharmaceutical and biotechnological industries that produce valuable proteins.

Original languageEnglish
Pages (from-to)2590-2593
Number of pages4
JournalJournal of Materials Chemistry
Volume21
Issue number8
DOIs
Publication statusPublished - 2011 Feb 28

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Terpolymers
Brushes
Drug products
Proteins
Pharmaceutical Preparations
Atom transfer radical polymerization
Muramidase
Enzymes
Industry

ASJC Scopus subject areas

  • Materials Chemistry
  • Chemistry(all)

Cite this

Thermo-responsive protein adsorbing materials for purifying pharmaceutical protein on exposed charging surface. / Nagase, Kenichi; Yuk, Simuck F.; Kobayashi, Jun; Kikuchi, Akihiko; Akiyama, Yoshikatsu; Kanazawa, Hideko; Okano, Teruo.

In: Journal of Materials Chemistry, Vol. 21, No. 8, 28.02.2011, p. 2590-2593.

Research output: Contribution to journalArticle

Nagase, Kenichi ; Yuk, Simuck F. ; Kobayashi, Jun ; Kikuchi, Akihiko ; Akiyama, Yoshikatsu ; Kanazawa, Hideko ; Okano, Teruo. / Thermo-responsive protein adsorbing materials for purifying pharmaceutical protein on exposed charging surface. In: Journal of Materials Chemistry. 2011 ; Vol. 21, No. 8. pp. 2590-2593.
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