Thermoresponsive interfaces grafted with high-density thermoresponsive polymers; Regulated cultured cell adhesion and detachment

Aya Mizutani, Akihiko Kikuchi, Jun Kobayashi, Yoshikatsu Akiyama, Hideko Kanazawa, Teruo Okano

Research output: Contribution to conferencePaper

Abstract

In the present research, thermoresponsive interfaces grafted with high-density poly(N-isopropylacrylamide) (PIPAAm) are prepared by surface-initiated atom transfer radical polymerization (ATRP) on poly(p-chloromethylstyrene)-cast polystyrene surfaces. Surface characterization revealed that thermoresponsive polymers were covalently grafted onto the polystyrene surfaces. Moreover, we investigated influence of thermoresponsive surface characteristics on adhesion/detachment behavior of cultured cells. Results suggest that control of the amount of grafted PIPAAm, and also the differences in its PIPAAm constructed structure influence cell adhesion/detachment control.

Original languageEnglish
Pages5399-5400
Number of pages2
Publication statusPublished - 2006 Dec 1
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period06/9/2006/9/22

Keywords

  • Cell culture
  • High-density polymer grafted surfaces
  • Poly(N-isopropylacrylamide)
  • Surface-initiated atom transfer radical polymerization
  • Thermoresponsive polymer

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Mizutani, A., Kikuchi, A., Kobayashi, J., Akiyama, Y., Kanazawa, H., & Okano, T. (2006). Thermoresponsive interfaces grafted with high-density thermoresponsive polymers; Regulated cultured cell adhesion and detachment. 5399-5400. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.