Thermoresponsive interfaces grafted with high-density thermoresponsive polymers; Regulated cultured cell adhesion and detachment

Aya Mizutani, Akihiko Kikuchi, Jun Kobayashi, Yoshikatsu Akiyama, Hideko Kanazawa, Teruo Okano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In the present research, thermoresponsive interfaces grafted with high-density poly(N-isopropylacrylamide) (PIPAAm) are prepared by surface-initiated atom transfer radical polymerization (ATRP) on poly(p-chloromethylstyrene)-cast polystyrene surfaces. Surface characterization revealed that thermoresponsive polymers were covalently grafted onto the polystyrene surfaces. Moreover, we investigated influence of thermoresponsive surface characteristics on adhesion/detachment behavior of cultured cells. Results suggest that control of the amount of grafted PIPAAm, and also the differences in its PIPAAm constructed structure influence cell adhesion/detachment control.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Pages5399-5400
Number of pages2
Volume55
Edition2
Publication statusPublished - 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period06/9/2006/9/22

Fingerprint

Cell adhesion
Polymers
Polystyrenes
Atom transfer radical polymerization
Adhesion
Cells

Keywords

  • Cell culture
  • High-density polymer grafted surfaces
  • Poly(N-isopropylacrylamide)
  • Surface-initiated atom transfer radical polymerization
  • Thermoresponsive polymer

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Mizutani, A., Kikuchi, A., Kobayashi, J., Akiyama, Y., Kanazawa, H., & Okano, T. (2006). Thermoresponsive interfaces grafted with high-density thermoresponsive polymers; Regulated cultured cell adhesion and detachment. In Polymer Preprints, Japan (2 ed., Vol. 55, pp. 5399-5400)

Thermoresponsive interfaces grafted with high-density thermoresponsive polymers; Regulated cultured cell adhesion and detachment. / Mizutani, Aya; Kikuchi, Akihiko; Kobayashi, Jun; Akiyama, Yoshikatsu; Kanazawa, Hideko; Okano, Teruo.

Polymer Preprints, Japan. Vol. 55 2. ed. 2006. p. 5399-5400.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mizutani, A, Kikuchi, A, Kobayashi, J, Akiyama, Y, Kanazawa, H & Okano, T 2006, Thermoresponsive interfaces grafted with high-density thermoresponsive polymers; Regulated cultured cell adhesion and detachment. in Polymer Preprints, Japan. 2 edn, vol. 55, pp. 5399-5400, 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan, 06/9/20.
Mizutani A, Kikuchi A, Kobayashi J, Akiyama Y, Kanazawa H, Okano T. Thermoresponsive interfaces grafted with high-density thermoresponsive polymers; Regulated cultured cell adhesion and detachment. In Polymer Preprints, Japan. 2 ed. Vol. 55. 2006. p. 5399-5400
Mizutani, Aya ; Kikuchi, Akihiko ; Kobayashi, Jun ; Akiyama, Yoshikatsu ; Kanazawa, Hideko ; Okano, Teruo. / Thermoresponsive interfaces grafted with high-density thermoresponsive polymers; Regulated cultured cell adhesion and detachment. Polymer Preprints, Japan. Vol. 55 2. ed. 2006. pp. 5399-5400
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AU - Kanazawa, Hideko

AU - Okano, Teruo

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