TY - GEN
T1 - Thin Layered Heterogeneous Vascularized 3D Tissue Models Constructed with Separated-Layer Collagen Microtube
AU - Itai, Shun
AU - Onoe, Hiroaki
N1 - Funding Information:
This work was partly supported by Grant-in Aid for Scientific Research (B) (26289060), Japan Society for the Promotion of Science (JSPS), Japan.
Publisher Copyright:
© 2019 IEEE.
PY - 2019/1
Y1 - 2019/1
N2 - We present an in vitro vascularized 3D cell co-culture, performed by a separated-layer collagen microtube device. Our device can co-culture endothelial and other cells in close position, while the collagen layers are separated into an outer support layer and an inner culture layer. The close distance between different types of cells enhances mutual cell interaction and enables us to observe the tissue structures clearly. Moreover, while collagen tubes are directly attached to silicone tubes, perfusion culture is easily performed by an external pump system. We believe that our device could help the fabrication of various vascularized tissue models in high activity, and contribute to the development of pharmacokinetic testing platforms and regenerative medicine.
AB - We present an in vitro vascularized 3D cell co-culture, performed by a separated-layer collagen microtube device. Our device can co-culture endothelial and other cells in close position, while the collagen layers are separated into an outer support layer and an inner culture layer. The close distance between different types of cells enhances mutual cell interaction and enables us to observe the tissue structures clearly. Moreover, while collagen tubes are directly attached to silicone tubes, perfusion culture is easily performed by an external pump system. We believe that our device could help the fabrication of various vascularized tissue models in high activity, and contribute to the development of pharmacokinetic testing platforms and regenerative medicine.
UR - http://www.scopus.com/inward/record.url?scp=85074376383&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074376383&partnerID=8YFLogxK
U2 - 10.1109/MEMSYS.2019.8870866
DO - 10.1109/MEMSYS.2019.8870866
M3 - Conference contribution
AN - SCOPUS:85074376383
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 118
EP - 119
BT - 2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems, MEMS 2019
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 32nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2019
Y2 - 27 January 2019 through 31 January 2019
ER -