Thin Layered Heterogeneous Vascularized 3D Tissue Models Constructed with Separated-Layer Collagen Microtube

Shun Itai; Hiroaki Onoe

doi:10.1109/MEMSYS.2019.8870866

Thin Layered Heterogeneous Vascularized 3D Tissue Models Constructed with Separated-Layer Collagen Microtube

Shun Itai, Hiroaki Onoe

Department of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We present an in vitro vascularized 3D cell co-culture, performed by a separated-layer collagen microtube device. Our device can co-culture endothelial and other cells in close position, while the collagen layers are separated into an outer support layer and an inner culture layer. The close distance between different types of cells enhances mutual cell interaction and enables us to observe the tissue structures clearly. Moreover, while collagen tubes are directly attached to silicone tubes, perfusion culture is easily performed by an external pump system. We believe that our device could help the fabrication of various vascularized tissue models in high activity, and contribute to the development of pharmacokinetic testing platforms and regenerative medicine.

Original language	English
Title of host publication	2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems, MEMS 2019
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	118-119
Number of pages	2
ISBN (Electronic)	9781728116105
DOIs	https://doi.org/10.1109/MEMSYS.2019.8870866
Publication status	Published - 2019 Jan
Event	32nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2019 - Seoul, Korea, Republic of Duration: 2019 Jan 27 → 2019 Jan 31

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume	2019-January
ISSN (Print)	1084-6999

Conference

Conference	32nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2019
Country	Korea, Republic of
City	Seoul
Period	19/1/27 → 19/1/31

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/MEMSYS.2019.8870866

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Cite this

Itai, S., & Onoe, H. (2019). Thin Layered Heterogeneous Vascularized 3D Tissue Models Constructed with Separated-Layer Collagen Microtube. In 2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems, MEMS 2019 (pp. 118-119). [8870866] (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2019-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMSYS.2019.8870866

Thin Layered Heterogeneous Vascularized 3D Tissue Models Constructed with Separated-Layer Collagen Microtube. / Itai, Shun; Onoe, Hiroaki.

2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems, MEMS 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 118-119 8870866 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2019-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Itai, S & Onoe, H 2019, Thin Layered Heterogeneous Vascularized 3D Tissue Models Constructed with Separated-Layer Collagen Microtube. in 2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems, MEMS 2019., 8870866, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2019-January, Institute of Electrical and Electronics Engineers Inc., pp. 118-119, 32nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2019, Seoul, Korea, Republic of, 19/1/27. https://doi.org/10.1109/MEMSYS.2019.8870866

Itai S, Onoe H. Thin Layered Heterogeneous Vascularized 3D Tissue Models Constructed with Separated-Layer Collagen Microtube. In 2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems, MEMS 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 118-119. 8870866. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2019.8870866

Itai, Shun ; Onoe, Hiroaki. / Thin Layered Heterogeneous Vascularized 3D Tissue Models Constructed with Separated-Layer Collagen Microtube. 2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems, MEMS 2019. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 118-119 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

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AB - We present an in vitro vascularized 3D cell co-culture, performed by a separated-layer collagen microtube device. Our device can co-culture endothelial and other cells in close position, while the collagen layers are separated into an outer support layer and an inner culture layer. The close distance between different types of cells enhances mutual cell interaction and enables us to observe the tissue structures clearly. Moreover, while collagen tubes are directly attached to silicone tubes, perfusion culture is easily performed by an external pump system. We believe that our device could help the fabrication of various vascularized tissue models in high activity, and contribute to the development of pharmacokinetic testing platforms and regenerative medicine.

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