Thin-section computed tomography findings of lung adenocarcinoma with inherent metastatic potential

Shigeki Suzuki, Keiju Aokage, Junji Yoshida, Genichiro Ishii, Yuki Matsumura, Tomohiro Haruki, Tomoyuki Hishida, Kanji Nagai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: The solid component of lung ground-glass nodules on thin-section computed tomography (TSCT) reflects cancer cell progression and invasiveness. The purpose of this study was to clarify the cut-off value of preoperative TSCT findings in treating a lesion suspected of being adenocarcinoma and to recognize the timing of surgical resection for lung nodules. Methods: We reevaluated the TSCT findings in 392 patients with clinical stage IA lung adenocarcinoma who underwent surgical resection between 2003 and 2007. We identified the clinical parameters that were most useful for predicting recurrence and identified a cut-off level for each parameter. Results: Recurrence was observed in 75 (19 %) of 392 patients (median follow-up: 7 years). The size of internal consolidation of a lung nodule (SCL) and the ratio of the SCL to the maximum tumor diameter (C/T ratio) were extracted as independent factors that predicted recurrence. Only 1 (0.3 %) patient each with a lung nodule C/T ratio ≤0.5 and SCL ≤10 mm recurred. These conditions were associated with a significantly better overall survival and recurrence-free survival. Conclusion: In patients with clinical stage I lung adenocarcinoma with a C/T ratio ≤0.5 and/or SCL ≤10 mm on TSCT, surgery is extremely likely to achieve a cure.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalSurgery Today
DOIs
Publication statusAccepted/In press - 2016 Sep 22
Externally publishedYes

Fingerprint

Tomography
Recurrence
Lung
Survival
Glass
Neoplasms
Adenocarcinoma
Adenocarcinoma of lung

Keywords

  • Adenocarcinoma
  • Consolidation tumor ratio
  • Ground-glass nodule
  • Surgery
  • Thin-section CT

ASJC Scopus subject areas

  • Surgery

Cite this

Suzuki, S., Aokage, K., Yoshida, J., Ishii, G., Matsumura, Y., Haruki, T., ... Nagai, K. (Accepted/In press). Thin-section computed tomography findings of lung adenocarcinoma with inherent metastatic potential. Surgery Today, 1-8. https://doi.org/10.1007/s00595-016-1416-3

Thin-section computed tomography findings of lung adenocarcinoma with inherent metastatic potential. / Suzuki, Shigeki; Aokage, Keiju; Yoshida, Junji; Ishii, Genichiro; Matsumura, Yuki; Haruki, Tomohiro; Hishida, Tomoyuki; Nagai, Kanji.

In: Surgery Today, 22.09.2016, p. 1-8.

Research output: Contribution to journalArticle

Suzuki, Shigeki ; Aokage, Keiju ; Yoshida, Junji ; Ishii, Genichiro ; Matsumura, Yuki ; Haruki, Tomohiro ; Hishida, Tomoyuki ; Nagai, Kanji. / Thin-section computed tomography findings of lung adenocarcinoma with inherent metastatic potential. In: Surgery Today. 2016 ; pp. 1-8.
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