Three-day regimen of oseltamivir for postexposure prophylaxis of influenza in wards

N. Ishiguro, R. Oyamada, Y. Nasuhara, T. Yamada, T. Miyamoto, S. Imai, K. Akizawa, T. Fukumoto, S. Iwasaki, H. Iijima, K. Ono

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Inpatients who had been in close contact with patients with influenza were given oseltamivir [75 mg capsules once daily for adults or 2 mg/kg (maximum of 75 mg) once daily for children] for three days as postexposure prophylaxis (PEP). The index patients with influenza were prescribed a neuraminidase inhibitor and were discharged immediately or transferred to isolation rooms. The protective efficacy of oseltamivir for three days was 93% overall [95% confidence interval (CI) 53–99%; P=0.023] and 94% for influenza A (95% CI 61–99%; P=0.017), which is comparable to that of seven- to 10-day regimens of oseltamivir as PEP.

Original languageEnglish
Pages (from-to)150-153
Number of pages4
JournalJournal of Hospital Infection
Volume94
Issue number2
DOIs
Publication statusPublished - 2016 Oct 1
Externally publishedYes

Keywords

  • Influenza
  • Oseltamivir
  • Postexposure prophylaxis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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