Three-dimensional cortex model including vascular structure for estimation of path length for optical imaging

Takahiro Kikuchi, Hiroyuki Takuwa, Kazuto Masamoto, Hiroshi Ito, Eiji Okada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optical imaging of hemoglobin concentration changes in the exposed cortex has been used to investigate the functional brain activation. The concentration changes in oxygenated and deoxygenated hemoglobin can be independently obtained from the dual- or multi-wavelength measurements of the change in reflectance of the exposed cortex and wavelengthdependent optical path length in the cortical tissues. In the previous studies, the partial optical path length were generally estimated by homogeneous and layered models. In reality, the concentration changes in the hemoglobin only occurs in the blood vessels. In this study, the partial optical path lengths in the blood vessels were estimated by the heterogeneous model including the blood vessel structure based upon the image acquired by two-photon microscopy. Light propagation in the exposed-cortex model is simulated to estimate the wavelength dependence of the partial optical path length in the blood vessels. The wavelength dependence of the partial optical path length for the heterogeneous model was different from that for the homogeneous model. In the wavelength range from 500 to 580 nm, the partial optical path length in the blood vessels was mainly affected by the structure of the blood vessels in the region shallower than 50 μm.

Original languageEnglish
Title of host publicationEuropean Conference on Biomedical Optics, ECBO 2013
PublisherOptical Society of America
ISBN (Print)9780819496461
Publication statusPublished - 2013 Jan 1
EventEuropean Conference on Biomedical Optics, ECBO 2013 - Munich, Germany
Duration: 2013 May 122013 May 16

Publication series

NameOptics InfoBase Conference Papers
ISSN (Electronic)2162-2701

Other

OtherEuropean Conference on Biomedical Optics, ECBO 2013
CountryGermany
CityMunich
Period13/5/1213/5/16

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Keywords

  • Medical and biomedical imaging
  • Photon migration

ASJC Scopus subject areas

  • Instrumentation
  • Atomic and Molecular Physics, and Optics

Cite this

Kikuchi, T., Takuwa, H., Masamoto, K., Ito, H., & Okada, E. (2013). Three-dimensional cortex model including vascular structure for estimation of path length for optical imaging. In European Conference on Biomedical Optics, ECBO 2013 (Optics InfoBase Conference Papers). Optical Society of America.