Three-dimensional cortex model including vascular structure for estimation of path length for optical imaging

Takahiro Kikuchi, Hiroyuki Takuwa, Kazuto Masamoto, Hiroshi Ito, Eiji Okada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optical imaging of hemoglobin concentration changes in the exposed cortex has been used to investigate the functional brain activation. The concentration changes in oxygenated and deoxygenated hemoglobin can be independently obtained from the dual-or multi-wavelength measurements of the change in reflectance of the exposed cortex and wavelength-dependent optical path length in the cortical tissues. In the previous studies, the partial optical path length were generally estimated by homogeneous and layered models. In reality, the concentration changes in the hemoglobin only occurs in the blood vessels. In this study, the partial optical path lengths in the blood vessels were estimated by the heterogeneous model including the blood vessel structure based upon the image acquired by two-photon microscopy. Light propagation in the exposed-cortex model is simulated to estimate the wavelength dependence of the partial optical path length in the blood vessels. The wavelength dependence of the partial optical path length for the heterogeneous model was different from that for the homogeneous model. In the wavelength range from 500 to 580 nm, the partial optical path length in the blood vessels was mainly affected by the structure of the blood vessels in the region shallower than 50 μm.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8799
DOIs
Publication statusPublished - 2013
EventDiffuse Optical Imaging IV - Munich, Germany
Duration: 2013 May 122013 May 14

Other

OtherDiffuse Optical Imaging IV
CountryGermany
CityMunich
Period13/5/1213/5/14

Fingerprint

cortexes
Optical Imaging
blood vessels
Blood vessels
optical paths
Blood Vessels
Imaging techniques
Hemoglobin
hemoglobin
Wavelength
Hemoglobins
wavelengths
Light propagation
Photons
brain
Microscopy
Brain
Microscopic examination
Chemical activation
activation

Keywords

  • Medical and biomedical imaging
  • Photon migration

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Kikuchi, T., Takuwa, H., Masamoto, K., Ito, H., & Okada, E. (2013). Three-dimensional cortex model including vascular structure for estimation of path length for optical imaging. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8799). [87990M] https://doi.org/10.1117/12.2032509

Three-dimensional cortex model including vascular structure for estimation of path length for optical imaging. / Kikuchi, Takahiro; Takuwa, Hiroyuki; Masamoto, Kazuto; Ito, Hiroshi; Okada, Eiji.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8799 2013. 87990M.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kikuchi, T, Takuwa, H, Masamoto, K, Ito, H & Okada, E 2013, Three-dimensional cortex model including vascular structure for estimation of path length for optical imaging. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8799, 87990M, Diffuse Optical Imaging IV, Munich, Germany, 13/5/12. https://doi.org/10.1117/12.2032509
Kikuchi T, Takuwa H, Masamoto K, Ito H, Okada E. Three-dimensional cortex model including vascular structure for estimation of path length for optical imaging. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8799. 2013. 87990M https://doi.org/10.1117/12.2032509
Kikuchi, Takahiro ; Takuwa, Hiroyuki ; Masamoto, Kazuto ; Ito, Hiroshi ; Okada, Eiji. / Three-dimensional cortex model including vascular structure for estimation of path length for optical imaging. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8799 2013.
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