Abstract
Background: Acral melanocytic nevi have parallel patterns on dermoscopy; however, it is not understood why pigment distributions exhibit such patterns. Aim: To clarify the reason why melanin distributions in acral melanocytic nevi exhibit a parallel pattern on dermoscopy. Methods: A serial sectioning perpendicular to the skin markings was performed, and each section was stained with modified Fontana-Masson staining to pick out melanin granules. These sections were then reconstructed to three-dimensional images by an image processing software, and these three-dimensional images were analyzed. Results: Melanin columns in the cornified layer were mainly seen in the dermoscopic images of acral melanocytic nevi. In the parallel-furrow pattern melanin columns were arranged vertically, and in the fibrillar pattern they were arranged in a slanting fashion. Conclusion: Melanin columns in the cornified layer, not melanin in the basal layer, mainly contribute to the dermoscopic pattern of acral melanocytic nevi.
| Original language | English |
|---|---|
| Pages (from-to) | 205-212 |
| Number of pages | 8 |
| Journal | Dermatology |
| Volume | 216 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2008 Mar |
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Keywords
- Acral melanocytic nevus
- Dermoscopy
- Fibrillar pattern
- Melanin column
- Parallel-furrow pattern
- Three-dimensional
ASJC Scopus subject areas
- Dermatology
Cite this
Three-dimensional melanin distribution of acral melanocytic nevi is reflected in dermoscopy features : Analysis of the parallel pattern. / Kimoto, M.; Sakamoto, Michiie; Iyatomi, H.; Tanaka, M.
In: Dermatology, Vol. 216, No. 3, 03.2008, p. 205-212.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Three-dimensional melanin distribution of acral melanocytic nevi is reflected in dermoscopy features
T2 - Analysis of the parallel pattern
AU - Kimoto, M.
AU - Sakamoto, Michiie
AU - Iyatomi, H.
AU - Tanaka, M.
PY - 2008/3
Y1 - 2008/3
N2 - Background: Acral melanocytic nevi have parallel patterns on dermoscopy; however, it is not understood why pigment distributions exhibit such patterns. Aim: To clarify the reason why melanin distributions in acral melanocytic nevi exhibit a parallel pattern on dermoscopy. Methods: A serial sectioning perpendicular to the skin markings was performed, and each section was stained with modified Fontana-Masson staining to pick out melanin granules. These sections were then reconstructed to three-dimensional images by an image processing software, and these three-dimensional images were analyzed. Results: Melanin columns in the cornified layer were mainly seen in the dermoscopic images of acral melanocytic nevi. In the parallel-furrow pattern melanin columns were arranged vertically, and in the fibrillar pattern they were arranged in a slanting fashion. Conclusion: Melanin columns in the cornified layer, not melanin in the basal layer, mainly contribute to the dermoscopic pattern of acral melanocytic nevi.
AB - Background: Acral melanocytic nevi have parallel patterns on dermoscopy; however, it is not understood why pigment distributions exhibit such patterns. Aim: To clarify the reason why melanin distributions in acral melanocytic nevi exhibit a parallel pattern on dermoscopy. Methods: A serial sectioning perpendicular to the skin markings was performed, and each section was stained with modified Fontana-Masson staining to pick out melanin granules. These sections were then reconstructed to three-dimensional images by an image processing software, and these three-dimensional images were analyzed. Results: Melanin columns in the cornified layer were mainly seen in the dermoscopic images of acral melanocytic nevi. In the parallel-furrow pattern melanin columns were arranged vertically, and in the fibrillar pattern they were arranged in a slanting fashion. Conclusion: Melanin columns in the cornified layer, not melanin in the basal layer, mainly contribute to the dermoscopic pattern of acral melanocytic nevi.
KW - Acral melanocytic nevus
KW - Dermoscopy
KW - Fibrillar pattern
KW - Melanin column
KW - Parallel-furrow pattern
KW - Three-dimensional
UR - http://www.scopus.com/inward/record.url?scp=40949142392&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40949142392&partnerID=8YFLogxK
U2 - 10.1159/000112927
DO - 10.1159/000112927
M3 - Article
C2 - 18182811
AN - SCOPUS:40949142392
VL - 216
SP - 205
EP - 212
JO - Dermatology
JF - Dermatology
SN - 1018-8665
IS - 3
ER -