Three-dimensional melanin distribution of acral melanocytic nevi is reflected in dermoscopy features: Analysis of the parallel pattern

M. Kimoto, Michiie Sakamoto, H. Iyatomi, M. Tanaka

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Acral melanocytic nevi have parallel patterns on dermoscopy; however, it is not understood why pigment distributions exhibit such patterns. Aim: To clarify the reason why melanin distributions in acral melanocytic nevi exhibit a parallel pattern on dermoscopy. Methods: A serial sectioning perpendicular to the skin markings was performed, and each section was stained with modified Fontana-Masson staining to pick out melanin granules. These sections were then reconstructed to three-dimensional images by an image processing software, and these three-dimensional images were analyzed. Results: Melanin columns in the cornified layer were mainly seen in the dermoscopic images of acral melanocytic nevi. In the parallel-furrow pattern melanin columns were arranged vertically, and in the fibrillar pattern they were arranged in a slanting fashion. Conclusion: Melanin columns in the cornified layer, not melanin in the basal layer, mainly contribute to the dermoscopic pattern of acral melanocytic nevi.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalDermatology
Volume216
Issue number3
DOIs
Publication statusPublished - 2008 Mar

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Dermoscopy
Pigmented Nevus
Melanins
Extremities
Three-Dimensional Imaging
Software
Staining and Labeling
Skin

Keywords

  • Acral melanocytic nevus
  • Dermoscopy
  • Fibrillar pattern
  • Melanin column
  • Parallel-furrow pattern
  • Three-dimensional

ASJC Scopus subject areas

  • Dermatology

Cite this

Three-dimensional melanin distribution of acral melanocytic nevi is reflected in dermoscopy features : Analysis of the parallel pattern. / Kimoto, M.; Sakamoto, Michiie; Iyatomi, H.; Tanaka, M.

In: Dermatology, Vol. 216, No. 3, 03.2008, p. 205-212.

Research output: Contribution to journalArticle

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AU - Tanaka, M.

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AB - Background: Acral melanocytic nevi have parallel patterns on dermoscopy; however, it is not understood why pigment distributions exhibit such patterns. Aim: To clarify the reason why melanin distributions in acral melanocytic nevi exhibit a parallel pattern on dermoscopy. Methods: A serial sectioning perpendicular to the skin markings was performed, and each section was stained with modified Fontana-Masson staining to pick out melanin granules. These sections were then reconstructed to three-dimensional images by an image processing software, and these three-dimensional images were analyzed. Results: Melanin columns in the cornified layer were mainly seen in the dermoscopic images of acral melanocytic nevi. In the parallel-furrow pattern melanin columns were arranged vertically, and in the fibrillar pattern they were arranged in a slanting fashion. Conclusion: Melanin columns in the cornified layer, not melanin in the basal layer, mainly contribute to the dermoscopic pattern of acral melanocytic nevi.

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