Three dimensional spheroids formation platform using micro-rotation flow

Hiroki Ota, Koji Deguchi, Ryosuke Yamamoto, Yutaka Kazoe, Koichi Hishida, Yohei Sato, Norihisa Miki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hepatocytes increase cell densities and acquire their liver-specific functions during the tissue formation from isolated cells. We developed three dimentional sphedoids formation platform using micro-rotation flow. Based on results of simulations and micro PIV, This chamber were designed to have a circular cylindrical shape with two inlets tangent to the circle at the bottom and two outlet channels at the top. The developed platform could not only form three dimensional spheroids, but also conrol sizes with micro meter scale only by a micro-rotation flow repeatedly. This platform will be applied to be new drug screening systems and hybrid artificial organs.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1183-1185
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 2009 Jan 1
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 2009 Nov 12009 Nov 5

Publication series

NameProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
CountryKorea, Republic of
CityJeju
Period09/11/109/11/5

Keywords

  • Micro-rotation
  • Photolithography
  • Tissue engineering

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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