Three job stress models/concepts and oxidative DNA damage in a sample of workers in Japan

Akiomi Inoue, Norito Kawakami, Masao Ishizaki, Masaji Tabata, Masao Tsuchiya, Miki Akiyama, Akiko Kitazume, Mitsuyo Kuroda, Akihito Shimazu

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective: Three job stress models/concepts (the job demands-control [DC] model, the effort-reward imbalance [ERI] model, and organizational justice) have been linked to coronary heart disease (CHD) at work. In recent years, oxidative DNA damage has been identified as a new risk factor for CHD. However, evidence for the association between these job stressors and oxidative DNA damage is limited. The present cross-sectional study investigated the association between these job stress models/concepts and oxidative DNA damage as a possible mediator of the adverse health effects of job stress. Methods: A total of 166 male and 51 female workers of a manufacturing factory in Japan were surveyed using a mailed questionnaire regarding job stressors and demographic, occupational, and lifestyle variables. Urinary concentrations of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, were also measured. Results: In male subjects, the urinary concentrations of 8-OHdG were significantly higher among the group with lower interactional justice, one of the two components of organizational justice; however, no association was observed with the DC model or the ERI model. In female subjects, high job demands/control ratio was significantly and positively associated with the urinary concentrations of 8-OHdG. Conclusion: Interactional justice among male workers and the DC model-based strain among female workers may be associated with increased urinary concentrations of 8-OHdG which possibly reflects oxidative DNA damage.

Original languageEnglish
Pages (from-to)329-334
Number of pages6
JournalJournal of Psychosomatic Research
Volume66
Issue number4
DOIs
Publication statusPublished - 2009 Apr 1
Externally publishedYes

Fingerprint

DNA Damage
Social Justice
Japan
Reward
Coronary Disease
Organizational Models
Life Style
Cross-Sectional Studies
Biomarkers
Demography
Health

Keywords

  • Coronary heart disease
  • Effort-reward imbalance model
  • Job demands-control model
  • Organizational justice
  • Urinary 8-OHdG

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Three job stress models/concepts and oxidative DNA damage in a sample of workers in Japan. / Inoue, Akiomi; Kawakami, Norito; Ishizaki, Masao; Tabata, Masaji; Tsuchiya, Masao; Akiyama, Miki; Kitazume, Akiko; Kuroda, Mitsuyo; Shimazu, Akihito.

In: Journal of Psychosomatic Research, Vol. 66, No. 4, 01.04.2009, p. 329-334.

Research output: Contribution to journalArticle

Inoue, A, Kawakami, N, Ishizaki, M, Tabata, M, Tsuchiya, M, Akiyama, M, Kitazume, A, Kuroda, M & Shimazu, A 2009, 'Three job stress models/concepts and oxidative DNA damage in a sample of workers in Japan', Journal of Psychosomatic Research, vol. 66, no. 4, pp. 329-334. https://doi.org/10.1016/j.jpsychores.2008.09.016
Inoue, Akiomi ; Kawakami, Norito ; Ishizaki, Masao ; Tabata, Masaji ; Tsuchiya, Masao ; Akiyama, Miki ; Kitazume, Akiko ; Kuroda, Mitsuyo ; Shimazu, Akihito. / Three job stress models/concepts and oxidative DNA damage in a sample of workers in Japan. In: Journal of Psychosomatic Research. 2009 ; Vol. 66, No. 4. pp. 329-334.
@article{d6361495e8344876807e8242a3503d27,
title = "Three job stress models/concepts and oxidative DNA damage in a sample of workers in Japan",
abstract = "Objective: Three job stress models/concepts (the job demands-control [DC] model, the effort-reward imbalance [ERI] model, and organizational justice) have been linked to coronary heart disease (CHD) at work. In recent years, oxidative DNA damage has been identified as a new risk factor for CHD. However, evidence for the association between these job stressors and oxidative DNA damage is limited. The present cross-sectional study investigated the association between these job stress models/concepts and oxidative DNA damage as a possible mediator of the adverse health effects of job stress. Methods: A total of 166 male and 51 female workers of a manufacturing factory in Japan were surveyed using a mailed questionnaire regarding job stressors and demographic, occupational, and lifestyle variables. Urinary concentrations of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, were also measured. Results: In male subjects, the urinary concentrations of 8-OHdG were significantly higher among the group with lower interactional justice, one of the two components of organizational justice; however, no association was observed with the DC model or the ERI model. In female subjects, high job demands/control ratio was significantly and positively associated with the urinary concentrations of 8-OHdG. Conclusion: Interactional justice among male workers and the DC model-based strain among female workers may be associated with increased urinary concentrations of 8-OHdG which possibly reflects oxidative DNA damage.",
keywords = "Coronary heart disease, Effort-reward imbalance model, Job demands-control model, Organizational justice, Urinary 8-OHdG",
author = "Akiomi Inoue and Norito Kawakami and Masao Ishizaki and Masaji Tabata and Masao Tsuchiya and Miki Akiyama and Akiko Kitazume and Mitsuyo Kuroda and Akihito Shimazu",
year = "2009",
month = "4",
day = "1",
doi = "10.1016/j.jpsychores.2008.09.016",
language = "English",
volume = "66",
pages = "329--334",
journal = "Journal of Psychosomatic Research",
issn = "0022-3999",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Three job stress models/concepts and oxidative DNA damage in a sample of workers in Japan

AU - Inoue, Akiomi

AU - Kawakami, Norito

AU - Ishizaki, Masao

AU - Tabata, Masaji

AU - Tsuchiya, Masao

AU - Akiyama, Miki

AU - Kitazume, Akiko

AU - Kuroda, Mitsuyo

AU - Shimazu, Akihito

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Objective: Three job stress models/concepts (the job demands-control [DC] model, the effort-reward imbalance [ERI] model, and organizational justice) have been linked to coronary heart disease (CHD) at work. In recent years, oxidative DNA damage has been identified as a new risk factor for CHD. However, evidence for the association between these job stressors and oxidative DNA damage is limited. The present cross-sectional study investigated the association between these job stress models/concepts and oxidative DNA damage as a possible mediator of the adverse health effects of job stress. Methods: A total of 166 male and 51 female workers of a manufacturing factory in Japan were surveyed using a mailed questionnaire regarding job stressors and demographic, occupational, and lifestyle variables. Urinary concentrations of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, were also measured. Results: In male subjects, the urinary concentrations of 8-OHdG were significantly higher among the group with lower interactional justice, one of the two components of organizational justice; however, no association was observed with the DC model or the ERI model. In female subjects, high job demands/control ratio was significantly and positively associated with the urinary concentrations of 8-OHdG. Conclusion: Interactional justice among male workers and the DC model-based strain among female workers may be associated with increased urinary concentrations of 8-OHdG which possibly reflects oxidative DNA damage.

AB - Objective: Three job stress models/concepts (the job demands-control [DC] model, the effort-reward imbalance [ERI] model, and organizational justice) have been linked to coronary heart disease (CHD) at work. In recent years, oxidative DNA damage has been identified as a new risk factor for CHD. However, evidence for the association between these job stressors and oxidative DNA damage is limited. The present cross-sectional study investigated the association between these job stress models/concepts and oxidative DNA damage as a possible mediator of the adverse health effects of job stress. Methods: A total of 166 male and 51 female workers of a manufacturing factory in Japan were surveyed using a mailed questionnaire regarding job stressors and demographic, occupational, and lifestyle variables. Urinary concentrations of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, were also measured. Results: In male subjects, the urinary concentrations of 8-OHdG were significantly higher among the group with lower interactional justice, one of the two components of organizational justice; however, no association was observed with the DC model or the ERI model. In female subjects, high job demands/control ratio was significantly and positively associated with the urinary concentrations of 8-OHdG. Conclusion: Interactional justice among male workers and the DC model-based strain among female workers may be associated with increased urinary concentrations of 8-OHdG which possibly reflects oxidative DNA damage.

KW - Coronary heart disease

KW - Effort-reward imbalance model

KW - Job demands-control model

KW - Organizational justice

KW - Urinary 8-OHdG

UR - http://www.scopus.com/inward/record.url?scp=62149113674&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62149113674&partnerID=8YFLogxK

U2 - 10.1016/j.jpsychores.2008.09.016

DO - 10.1016/j.jpsychores.2008.09.016

M3 - Article

VL - 66

SP - 329

EP - 334

JO - Journal of Psychosomatic Research

JF - Journal of Psychosomatic Research

SN - 0022-3999

IS - 4

ER -