Three new malyngamides from the marine cyanobacterium moorea producens

Kosuke Sueyoshi, Aki Yamano, Kaori Ozaki, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Three new compounds of the malyngamide series, 6,8-di-O-acetylmalyngamide 2 (1), 6-O-acetylmalyngamide 2 (2), and N-demethyl-isomalyngamide I (3), were isolated from the marine cyanobacterium Moorea producens. Their structures were determined by spectroscopic analysis and chemical derivatization and degradation. These compounds stimulated glucose uptake in cultured L6 myotubes. In particular, 6,8-di-O-acetylmalyngamide 2 (1) showed potent activity and activated adenosine monophosphate-activated protein kinase (AMPK).

Original languageEnglish
Article number367
JournalMarine Drugs
Volume15
Issue number12
DOIs
Publication statusPublished - 2017 Dec

Keywords

  • AMPK
  • Glucose uptake
  • Malyngamides
  • Marine cyanobacteria

ASJC Scopus subject areas

  • Drug Discovery

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