Three new malyngamides from the marine cyanobacterium moorea producens

Kosuke Sueyoshi; Aki Yamano; Kaori Ozaki; Shimpei Sumimoto; Arihiro Iwasaki; Kiyotake Suenaga; Toshiaki Teruya

doi:10.3390/md15120367

Three new malyngamides from the marine cyanobacterium moorea producens

Kosuke Sueyoshi, Aki Yamano, Kaori Ozaki, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Three new compounds of the malyngamide series, 6,8-di-O-acetylmalyngamide 2 (1), 6-O-acetylmalyngamide 2 (2), and N-demethyl-isomalyngamide I (3), were isolated from the marine cyanobacterium Moorea producens. Their structures were determined by spectroscopic analysis and chemical derivatization and degradation. These compounds stimulated glucose uptake in cultured L6 myotubes. In particular, 6,8-di-O-acetylmalyngamide 2 (1) showed potent activity and activated adenosine monophosphate-activated protein kinase (AMPK).

Original language	English
Article number	367
Journal	Marine Drugs
Volume	15
Issue number	12
DOIs	https://doi.org/10.3390/md15120367
Publication status	Published - 2017 Dec

Keywords

AMPK
Glucose uptake
Malyngamides
Marine cyanobacteria

ASJC Scopus subject areas

Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/md15120367

Cite this

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title = "Three new malyngamides from the marine cyanobacterium moorea producens",

abstract = "Three new compounds of the malyngamide series, 6,8-di-O-acetylmalyngamide 2 (1), 6-O-acetylmalyngamide 2 (2), and N-demethyl-isomalyngamide I (3), were isolated from the marine cyanobacterium Moorea producens. Their structures were determined by spectroscopic analysis and chemical derivatization and degradation. These compounds stimulated glucose uptake in cultured L6 myotubes. In particular, 6,8-di-O-acetylmalyngamide 2 (1) showed potent activity and activated adenosine monophosphate-activated protein kinase (AMPK).",

keywords = "AMPK, Glucose uptake, Malyngamides, Marine cyanobacteria",

author = "Kosuke Sueyoshi and Aki Yamano and Kaori Ozaki and Shimpei Sumimoto and Arihiro Iwasaki and Kiyotake Suenaga and Toshiaki Teruya",

note = "Funding Information: Acknowledgments: This work was supported in part by a Grant-in-Aid for Young Scientists (B) (21710237) from the Ministry of Education, Culture, Sports, Science and Technology, Japan; University of the Ryukyus Strategic Research Grant. Publisher Copyright: {\textcopyright} 2017 by the authors.",

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doi = "10.3390/md15120367",

language = "English",

volume = "15",

journal = "Marine Drugs",

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T1 - Three new malyngamides from the marine cyanobacterium moorea producens

AU - Sueyoshi, Kosuke

AU - Yamano, Aki

AU - Ozaki, Kaori

AU - Sumimoto, Shimpei

AU - Iwasaki, Arihiro

AU - Suenaga, Kiyotake

AU - Teruya, Toshiaki

N1 - Funding Information: Acknowledgments: This work was supported in part by a Grant-in-Aid for Young Scientists (B) (21710237) from the Ministry of Education, Culture, Sports, Science and Technology, Japan; University of the Ryukyus Strategic Research Grant. Publisher Copyright: © 2017 by the authors.

PY - 2017/12

Y1 - 2017/12

N2 - Three new compounds of the malyngamide series, 6,8-di-O-acetylmalyngamide 2 (1), 6-O-acetylmalyngamide 2 (2), and N-demethyl-isomalyngamide I (3), were isolated from the marine cyanobacterium Moorea producens. Their structures were determined by spectroscopic analysis and chemical derivatization and degradation. These compounds stimulated glucose uptake in cultured L6 myotubes. In particular, 6,8-di-O-acetylmalyngamide 2 (1) showed potent activity and activated adenosine monophosphate-activated protein kinase (AMPK).

AB - Three new compounds of the malyngamide series, 6,8-di-O-acetylmalyngamide 2 (1), 6-O-acetylmalyngamide 2 (2), and N-demethyl-isomalyngamide I (3), were isolated from the marine cyanobacterium Moorea producens. Their structures were determined by spectroscopic analysis and chemical derivatization and degradation. These compounds stimulated glucose uptake in cultured L6 myotubes. In particular, 6,8-di-O-acetylmalyngamide 2 (1) showed potent activity and activated adenosine monophosphate-activated protein kinase (AMPK).

KW - AMPK

KW - Glucose uptake

KW - Malyngamides

KW - Marine cyanobacteria

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Three new malyngamides from the marine cyanobacterium moorea producens

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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