Three new sulfur-containing alkaloids, polycarpaurines A, B, and C, from an Indonesian ascidian Polycarpa aurata

Weifang Wang, Taiko Oda, Ayako Fujita, Remy E P Mangindaan, Takahiro Nakazawa, Kazuyo Ukai, Hisayoshi Kobayashi, Michio Namikoshi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Three new sulfur-containing alkaloids, polycarpaurines A (1), B (2), and C (3) were isolated from the tropical ascidian Polycarpa aurata collected in Indonesia, together with six known compounds (4-9). The structures of new compounds were assigned on the basis of their spectral data. Compounds 1, 3, 4, and 8 inhibited colony formation of Chinese hamster V79 cells with EC50 values of 6.8, 8.6, 3.8, and 10 μM, respectively. Compounds 2 and 7 showed modest activity against V79 cells (EC50>10 μM).

Original languageEnglish
Pages (from-to)409-412
Number of pages4
JournalTetrahedron
Volume63
Issue number2
DOIs
Publication statusPublished - 2007 Jan 8

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Urochordata
Sulfur
Alkaloids
Indonesia
Cricetulus
8-1 compound

Keywords

  • Ascidian
  • Polycarpa aurata
  • Polycarpaurine
  • Structure assignment
  • Sulfur-containing alkaloid

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Wang, W., Oda, T., Fujita, A., Mangindaan, R. E. P., Nakazawa, T., Ukai, K., ... Namikoshi, M. (2007). Three new sulfur-containing alkaloids, polycarpaurines A, B, and C, from an Indonesian ascidian Polycarpa aurata. Tetrahedron, 63(2), 409-412. https://doi.org/10.1016/j.tet.2006.10.060

Three new sulfur-containing alkaloids, polycarpaurines A, B, and C, from an Indonesian ascidian Polycarpa aurata. / Wang, Weifang; Oda, Taiko; Fujita, Ayako; Mangindaan, Remy E P; Nakazawa, Takahiro; Ukai, Kazuyo; Kobayashi, Hisayoshi; Namikoshi, Michio.

In: Tetrahedron, Vol. 63, No. 2, 08.01.2007, p. 409-412.

Research output: Contribution to journalArticle

Wang, W, Oda, T, Fujita, A, Mangindaan, REP, Nakazawa, T, Ukai, K, Kobayashi, H & Namikoshi, M 2007, 'Three new sulfur-containing alkaloids, polycarpaurines A, B, and C, from an Indonesian ascidian Polycarpa aurata', Tetrahedron, vol. 63, no. 2, pp. 409-412. https://doi.org/10.1016/j.tet.2006.10.060
Wang, Weifang ; Oda, Taiko ; Fujita, Ayako ; Mangindaan, Remy E P ; Nakazawa, Takahiro ; Ukai, Kazuyo ; Kobayashi, Hisayoshi ; Namikoshi, Michio. / Three new sulfur-containing alkaloids, polycarpaurines A, B, and C, from an Indonesian ascidian Polycarpa aurata. In: Tetrahedron. 2007 ; Vol. 63, No. 2. pp. 409-412.
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