Three new sulfur-containing alkaloids, polycarpaurines A, B, and C, from an Indonesian ascidian Polycarpa aurata

Weifang Wang, Taiko Oda, Ayako Fujita, Remy E.P. Mangindaan, Takahiro Nakazawa, Kazuyo Ukai, Hisayoshi Kobayashi, Michio Namikoshi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Three new sulfur-containing alkaloids, polycarpaurines A (1), B (2), and C (3) were isolated from the tropical ascidian Polycarpa aurata collected in Indonesia, together with six known compounds (4-9). The structures of new compounds were assigned on the basis of their spectral data. Compounds 1, 3, 4, and 8 inhibited colony formation of Chinese hamster V79 cells with EC50 values of 6.8, 8.6, 3.8, and 10 μM, respectively. Compounds 2 and 7 showed modest activity against V79 cells (EC50>10 μM).

Original languageEnglish
Pages (from-to)409-412
Number of pages4
JournalTetrahedron
Volume63
Issue number2
DOIs
Publication statusPublished - 2007 Jan 8

Keywords

  • Ascidian
  • Polycarpa aurata
  • Polycarpaurine
  • Structure assignment
  • Sulfur-containing alkaloid

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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