Thrombotic thrombocytopenic purpura in two patients with systemic lupus erythematosus

Clinical significance of anti-platelet antibodies

Yoshihiro Itoh, Hiromi Sekine, Osamu Hosono, Tsutomu Takeuchi, Jun Koide, Makoto Takano, Tohru Abe

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a clinical syndrome of unknown etiology and has a high mortality rate due to disseminated platelet thrombi. However, the mechanism of platelet agglutination is not understood. Although an immunological mechanism has been suggested as the basis for the pathogenesis of TTP, any possible immunemediated etiology remains unclear. The association of TTP with systemic lupus erythematosus (SLE) affords a unique opportunity to study such possibilities, because SLE is a prototype of autoimmune disease. This report describes two patients with SLE who developed TTP. The development of anti-platelet antibodies is one possible immunological mechanism for platelet agglutination in patients with SLE complicated by TTP. More importantly, patient J.Y., who had anti-platelet antibodies, responded dramatically to high doses of prednisolone.

Original languageEnglish
Pages (from-to)125-136
Number of pages12
JournalClinical Immunology and Immunopathology
Volume57
Issue number1
DOIs
Publication statusPublished - 1990
Externally publishedYes

Fingerprint

Thrombotic Thrombocytopenic Purpura
Systemic Lupus Erythematosus
Anti-Idiotypic Antibodies
Blood Platelets
Agglutination
Prednisolone
Autoimmune Diseases
Thrombosis
Mortality

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Thrombotic thrombocytopenic purpura in two patients with systemic lupus erythematosus : Clinical significance of anti-platelet antibodies. / Itoh, Yoshihiro; Sekine, Hiromi; Hosono, Osamu; Takeuchi, Tsutomu; Koide, Jun; Takano, Makoto; Abe, Tohru.

In: Clinical Immunology and Immunopathology, Vol. 57, No. 1, 1990, p. 125-136.

Research output: Contribution to journalArticle

Itoh, Yoshihiro ; Sekine, Hiromi ; Hosono, Osamu ; Takeuchi, Tsutomu ; Koide, Jun ; Takano, Makoto ; Abe, Tohru. / Thrombotic thrombocytopenic purpura in two patients with systemic lupus erythematosus : Clinical significance of anti-platelet antibodies. In: Clinical Immunology and Immunopathology. 1990 ; Vol. 57, No. 1. pp. 125-136.
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