Thymectomy in ulcerative colitis

A report of cases over a 13 year period

M. Tsuchiya, T. Hibi, M. Watanabe, M. Ohara, Haruhiko Ogata, Yasushi Iwao, N. Watanabe, S. Aiso, H. Asakura, H. Yoshimatsu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Seventy eight patients with ulcerative colitis were treated by thymectomy combined with conventional therapy. An interim analysis was made after a median follow-up of 40 months in the thymectomized group and after 25 months in 173 from a non-thymectomized group. The percentage of remission periods in the thymectomized group was significantly higher than that in the nonthymectomized group as estimated by the 'patient-month' method. Histological examination of the excised thymus revealed hyperplasia of the thymic epithelial cells and/or the formation of lymphoid follicles. Anticolon antibody activity of the serum from the thymectomized patients decreased gradually and disappeared in 5 years or more. 'Thymectomy via the suprasternal notch with parasternal incision' which was applied in this study, is simple and not invasive. Therefore, it is recommended that thymectomy should be considered as one of the treatments for patients who are resistant to conventional therapy.

Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalThymus
Volume17
Issue number2
Publication statusPublished - 1991

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Thymectomy
Ulcerative Colitis
Thymus Hyperplasia
Therapeutics
Epithelial Cells
Antibodies
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Tsuchiya, M., Hibi, T., Watanabe, M., Ohara, M., Ogata, H., Iwao, Y., ... Yoshimatsu, H. (1991). Thymectomy in ulcerative colitis: A report of cases over a 13 year period. Thymus, 17(2), 67-73.

Thymectomy in ulcerative colitis : A report of cases over a 13 year period. / Tsuchiya, M.; Hibi, T.; Watanabe, M.; Ohara, M.; Ogata, Haruhiko; Iwao, Yasushi; Watanabe, N.; Aiso, S.; Asakura, H.; Yoshimatsu, H.

In: Thymus, Vol. 17, No. 2, 1991, p. 67-73.

Research output: Contribution to journalArticle

Tsuchiya, M, Hibi, T, Watanabe, M, Ohara, M, Ogata, H, Iwao, Y, Watanabe, N, Aiso, S, Asakura, H & Yoshimatsu, H 1991, 'Thymectomy in ulcerative colitis: A report of cases over a 13 year period', Thymus, vol. 17, no. 2, pp. 67-73.
Tsuchiya M, Hibi T, Watanabe M, Ohara M, Ogata H, Iwao Y et al. Thymectomy in ulcerative colitis: A report of cases over a 13 year period. Thymus. 1991;17(2):67-73.
Tsuchiya, M. ; Hibi, T. ; Watanabe, M. ; Ohara, M. ; Ogata, Haruhiko ; Iwao, Yasushi ; Watanabe, N. ; Aiso, S. ; Asakura, H. ; Yoshimatsu, H. / Thymectomy in ulcerative colitis : A report of cases over a 13 year period. In: Thymus. 1991 ; Vol. 17, No. 2. pp. 67-73.
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