Thymoma-associated graft-versus-host disease-like erythroderma

Tomoyuki Nakagiri, Meinoshin Okumura, Masayoshi Inoue, Masato Minami, Eiji Kiyohara, Noriko Umegaki, Toshiaki Nakamura, Yasuhiko Tomita, Ichirou Katayama, Katsuyuki Aozasa

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18 Citations (Scopus)

Abstract

We report a 40-year-old woman with recurrent thymoma associated with myasthenia gravis, in whom an unusual form of erythroderma developed. A histological examination revealed a graft-versus-host disease (GVHD)-like reaction. After high-dose steroid therapy, the metastatic thymoma lesion in the abdominal cavity was reduced in size from 9.5 × 6 × 7.5 cm to 4 × 3 × 1 cm in diameter. Nevertheless, the GVHD-like erythroderma become aggravated, her condition worsened, and the patient finally suffered from respiratory failure and died of sepsis. A GVHD-like reaction may be a rare presentation of thymoma-associated immunological disorders such as myasthenia gravis or pure red cell aplasia. Herein, we discuss the present case and review pertinent reports of thymoma cases associated with GVHD.

Original languageEnglish
Pages (from-to)1130-1132
Number of pages3
JournalJournal of Thoracic Oncology
Volume2
Issue number12
DOIs
Publication statusPublished - 2007 Dec

Keywords

  • Graft-versus-host disease-like erythroderma
  • Thymoma
  • Thymoma-associated immunological disorder

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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    Nakagiri, T., Okumura, M., Inoue, M., Minami, M., Kiyohara, E., Umegaki, N., Nakamura, T., Tomita, Y., Katayama, I., & Aozasa, K. (2007). Thymoma-associated graft-versus-host disease-like erythroderma. Journal of Thoracic Oncology, 2(12), 1130-1132. https://doi.org/10.1097/JTO.0b013e31815ba23a