Thymoma with pemphigus foliaceus

Kei Takeshita, Maki Amano, Takayuki Shimizu, Yoshitaka Oyamada, Tomohiro Abiko, Koichi Kobayashi, Yuko Futei, Masayuki Amagai, Shigeru Kuramochi, Koichiro Asano, Kazuhiro Yamaguchi

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


A 75-year-old Japanese woman was referred to us because of an anterior mediastinal mass. Crusts and shallow erosions developed 10 months earlier on her upper chest, back, and scalp. Pemphigus foliaceus was diagnosed based on histological examination of skin biopsy specimens and positivity for serum anti-desmoglein 1 antibody by enzyme-linked immunosorbent assay. Neurological examination and electromyography ruled out myasthenia gravis. Total thymectomy was performed, and the postoperative pathology studies showed mixed lymphoepithelial thymoma. One year after the resection, the eruption and alopecia improved and the serum anti-desmoglein 1 antibody titer decreased, suggesting a beneficial effect of thymectomy on thymomarelated pemphigus.

Original languageEnglish
Pages (from-to)742-747
Number of pages6
JournalInternal Medicine
Issue number9
Publication statusPublished - 2000 Sept


  • Anti-desmoglein 1 antibody
  • Thymectomy

ASJC Scopus subject areas

  • Internal Medicine


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