Thymoma with pemphigus foliaceus

Kei Takeshita; Maki Amano; Takayuki Shimizu; Yoshitaka Oyamada; Tomohiro Abiko; Koichi Kobayashi; Yuko Futei; Masayuki Amagai; Shigeru Kuramochi; Koichiro Asano; Kazuhiro Yamaguchi

doi:10.2169/internalmedicine.39.742

Thymoma with pemphigus foliaceus

Kei Takeshita, Maki Amano, Takayuki Shimizu, Yoshitaka Oyamada, Tomohiro Abiko, Koichi Kobayashi, Yuko Futei, Masayuki Amagai, Shigeru Kuramochi, Koichiro Asano, Kazuhiro Yamaguchi

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

A 75-year-old Japanese woman was referred to us because of an anterior mediastinal mass. Crusts and shallow erosions developed 10 months earlier on her upper chest, back, and scalp. Pemphigus foliaceus was diagnosed based on histological examination of skin biopsy specimens and positivity for serum anti-desmoglein 1 antibody by enzyme-linked immunosorbent assay. Neurological examination and electromyography ruled out myasthenia gravis. Total thymectomy was performed, and the postoperative pathology studies showed mixed lymphoepithelial thymoma. One year after the resection, the eruption and alopecia improved and the serum anti-desmoglein 1 antibody titer decreased, suggesting a beneficial effect of thymectomy on thymomarelated pemphigus.

Original language	English
Pages (from-to)	742-747
Number of pages	6
Journal	Internal Medicine
Volume	39
Issue number	9
DOIs	https://doi.org/10.2169/internalmedicine.39.742
Publication status	Published - 2000 Sept

Keywords

Anti-desmoglein 1 antibody
Thymectomy

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.39.742

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title = "Thymoma with pemphigus foliaceus",

abstract = "A 75-year-old Japanese woman was referred to us because of an anterior mediastinal mass. Crusts and shallow erosions developed 10 months earlier on her upper chest, back, and scalp. Pemphigus foliaceus was diagnosed based on histological examination of skin biopsy specimens and positivity for serum anti-desmoglein 1 antibody by enzyme-linked immunosorbent assay. Neurological examination and electromyography ruled out myasthenia gravis. Total thymectomy was performed, and the postoperative pathology studies showed mixed lymphoepithelial thymoma. One year after the resection, the eruption and alopecia improved and the serum anti-desmoglein 1 antibody titer decreased, suggesting a beneficial effect of thymectomy on thymomarelated pemphigus.",

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AU - Takeshita, Kei

AU - Amano, Maki

AU - Shimizu, Takayuki

AU - Oyamada, Yoshitaka

AU - Abiko, Tomohiro

AU - Kobayashi, Koichi

AU - Futei, Yuko

AU - Amagai, Masayuki

AU - Kuramochi, Shigeru

AU - Asano, Koichiro

AU - Yamaguchi, Kazuhiro

PY - 2000/9

Y1 - 2000/9

N2 - A 75-year-old Japanese woman was referred to us because of an anterior mediastinal mass. Crusts and shallow erosions developed 10 months earlier on her upper chest, back, and scalp. Pemphigus foliaceus was diagnosed based on histological examination of skin biopsy specimens and positivity for serum anti-desmoglein 1 antibody by enzyme-linked immunosorbent assay. Neurological examination and electromyography ruled out myasthenia gravis. Total thymectomy was performed, and the postoperative pathology studies showed mixed lymphoepithelial thymoma. One year after the resection, the eruption and alopecia improved and the serum anti-desmoglein 1 antibody titer decreased, suggesting a beneficial effect of thymectomy on thymomarelated pemphigus.

AB - A 75-year-old Japanese woman was referred to us because of an anterior mediastinal mass. Crusts and shallow erosions developed 10 months earlier on her upper chest, back, and scalp. Pemphigus foliaceus was diagnosed based on histological examination of skin biopsy specimens and positivity for serum anti-desmoglein 1 antibody by enzyme-linked immunosorbent assay. Neurological examination and electromyography ruled out myasthenia gravis. Total thymectomy was performed, and the postoperative pathology studies showed mixed lymphoepithelial thymoma. One year after the resection, the eruption and alopecia improved and the serum anti-desmoglein 1 antibody titer decreased, suggesting a beneficial effect of thymectomy on thymomarelated pemphigus.

KW - Anti-desmoglein 1 antibody

KW - Thymectomy

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JF - Internal Medicine

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Thymoma with pemphigus foliaceus

Abstract

Keywords

ASJC Scopus subject areas

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