Thyroglobulin concentration measurement in fine-needle aspiration fluid from cystic cervical lymph node metastases of papillary thyroid carcinoma

Yozo Inagaki, Koji Sakamoto, Yasuhiro Inoue, Yorihisa Imanishi, Toshiki Tomita, Seiichi Shinden, Hiroyuki Ozawa, Ryoichi Fujii, Seiji Shigetomi, Takahisa Watabe, Hiroyuki Yamada, Kaoru Ogawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Combining ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI) and fine-needle aspiration cytology (FNAC) usually results in the best preoperative diagnosis of cervical masses, including neoplasms. This may not be tnie, however, especially in occult papillary thyroid carcinoma (PTC) associated with single cystic cervical lymph node metastasis. We assessed the role of thyroglobulin measurement in FNA fluid (FNATg) in differentially diagnosing cystic cervical mass lesions, including PTC cystic lymph node metastasis. Methods: We reviewed the records of 17 subjects with cervical cystic masses undergoing both FNATg measure ment and surgery. FNA was done under ultrasonographic guidance. We also measured FNATg concentrations from extrathyroid lesions, consisting of cystic cervical lymph node metastases and benign cystic lesions. Results: Pathological diagnosis involved 5 PTC lymph node metastases, 3 lateral cervical cysts, 7 thyroglossal duct cysts, and 2 squamous cell carcinoma (lung and oropharynx) lymph node metastases. FNATg of PTC lymph node metastasis was much higher than the reference range of blood serum thyroglobulin, although much lower for the lateral cervical cyst detection threshold. FNAC and FNATg measurement are thought to be mutually complementary in the differential-diagnosis of PTC cystic lymph node metastasis. Conclusion : High concentrations of FNATg in a cystic cervical mass is considered specific to PTC lymph node metastasis, indicating its usefulness in distinguish PTC cystic metastasis from other cystic lesions. Including FNATg measurement with FNAC may thus improve preoperative diagnosis accuracy without additionally stressing subjects with PTC cystic lymph node metastasis.

Original languageEnglish
Pages (from-to)912-916
Number of pages5
JournalJournal of Otolaryngology of Japan
Volume114
Issue number12
DOIs
Publication statusPublished - 2011 Dec

Fingerprint

Thyroglobulin
Fine Needle Biopsy
Lymph Nodes
Neoplasm Metastasis
Periodontal Cyst
Cell Biology
Thyroglossal Cyst
Papillary Thyroid cancer
Oropharynx
Squamous Cell Carcinoma
Ultrasonography
Reference Values
Differential Diagnosis
Tomography
Magnetic Resonance Imaging
Lung

Keywords

  • Cervical lymph node metastases
  • Cystic cervical lesion fine-needle aspiration cytology (FNAC)
  • Papillary thyroid carcinoma
  • Thyroglobulin

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Thyroglobulin concentration measurement in fine-needle aspiration fluid from cystic cervical lymph node metastases of papillary thyroid carcinoma. / Inagaki, Yozo; Sakamoto, Koji; Inoue, Yasuhiro; Imanishi, Yorihisa; Tomita, Toshiki; Shinden, Seiichi; Ozawa, Hiroyuki; Fujii, Ryoichi; Shigetomi, Seiji; Watabe, Takahisa; Yamada, Hiroyuki; Ogawa, Kaoru.

In: Journal of Otolaryngology of Japan, Vol. 114, No. 12, 12.2011, p. 912-916.

Research output: Contribution to journalArticle

Inagaki, Yozo ; Sakamoto, Koji ; Inoue, Yasuhiro ; Imanishi, Yorihisa ; Tomita, Toshiki ; Shinden, Seiichi ; Ozawa, Hiroyuki ; Fujii, Ryoichi ; Shigetomi, Seiji ; Watabe, Takahisa ; Yamada, Hiroyuki ; Ogawa, Kaoru. / Thyroglobulin concentration measurement in fine-needle aspiration fluid from cystic cervical lymph node metastases of papillary thyroid carcinoma. In: Journal of Otolaryngology of Japan. 2011 ; Vol. 114, No. 12. pp. 912-916.
@article{2fba8116bbb44881b8c833087e2fecd1,
title = "Thyroglobulin concentration measurement in fine-needle aspiration fluid from cystic cervical lymph node metastases of papillary thyroid carcinoma",
abstract = "Background: Combining ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI) and fine-needle aspiration cytology (FNAC) usually results in the best preoperative diagnosis of cervical masses, including neoplasms. This may not be tnie, however, especially in occult papillary thyroid carcinoma (PTC) associated with single cystic cervical lymph node metastasis. We assessed the role of thyroglobulin measurement in FNA fluid (FNATg) in differentially diagnosing cystic cervical mass lesions, including PTC cystic lymph node metastasis. Methods: We reviewed the records of 17 subjects with cervical cystic masses undergoing both FNATg measure ment and surgery. FNA was done under ultrasonographic guidance. We also measured FNATg concentrations from extrathyroid lesions, consisting of cystic cervical lymph node metastases and benign cystic lesions. Results: Pathological diagnosis involved 5 PTC lymph node metastases, 3 lateral cervical cysts, 7 thyroglossal duct cysts, and 2 squamous cell carcinoma (lung and oropharynx) lymph node metastases. FNATg of PTC lymph node metastasis was much higher than the reference range of blood serum thyroglobulin, although much lower for the lateral cervical cyst detection threshold. FNAC and FNATg measurement are thought to be mutually complementary in the differential-diagnosis of PTC cystic lymph node metastasis. Conclusion : High concentrations of FNATg in a cystic cervical mass is considered specific to PTC lymph node metastasis, indicating its usefulness in distinguish PTC cystic metastasis from other cystic lesions. Including FNATg measurement with FNAC may thus improve preoperative diagnosis accuracy without additionally stressing subjects with PTC cystic lymph node metastasis.",
keywords = "Cervical lymph node metastases, Cystic cervical lesion fine-needle aspiration cytology (FNAC), Papillary thyroid carcinoma, Thyroglobulin",
author = "Yozo Inagaki and Koji Sakamoto and Yasuhiro Inoue and Yorihisa Imanishi and Toshiki Tomita and Seiichi Shinden and Hiroyuki Ozawa and Ryoichi Fujii and Seiji Shigetomi and Takahisa Watabe and Hiroyuki Yamada and Kaoru Ogawa",
year = "2011",
month = "12",
doi = "10.3950/jibiinkoka.114.912",
language = "English",
volume = "114",
pages = "912--916",
journal = "Journal of Otolaryngology of Japan",
issn = "0030-6622",
publisher = "Oto-Rhino-Laryngological Society of Japan Inc.",
number = "12",

}

TY - JOUR

T1 - Thyroglobulin concentration measurement in fine-needle aspiration fluid from cystic cervical lymph node metastases of papillary thyroid carcinoma

AU - Inagaki, Yozo

AU - Sakamoto, Koji

AU - Inoue, Yasuhiro

AU - Imanishi, Yorihisa

AU - Tomita, Toshiki

AU - Shinden, Seiichi

AU - Ozawa, Hiroyuki

AU - Fujii, Ryoichi

AU - Shigetomi, Seiji

AU - Watabe, Takahisa

AU - Yamada, Hiroyuki

AU - Ogawa, Kaoru

PY - 2011/12

Y1 - 2011/12

N2 - Background: Combining ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI) and fine-needle aspiration cytology (FNAC) usually results in the best preoperative diagnosis of cervical masses, including neoplasms. This may not be tnie, however, especially in occult papillary thyroid carcinoma (PTC) associated with single cystic cervical lymph node metastasis. We assessed the role of thyroglobulin measurement in FNA fluid (FNATg) in differentially diagnosing cystic cervical mass lesions, including PTC cystic lymph node metastasis. Methods: We reviewed the records of 17 subjects with cervical cystic masses undergoing both FNATg measure ment and surgery. FNA was done under ultrasonographic guidance. We also measured FNATg concentrations from extrathyroid lesions, consisting of cystic cervical lymph node metastases and benign cystic lesions. Results: Pathological diagnosis involved 5 PTC lymph node metastases, 3 lateral cervical cysts, 7 thyroglossal duct cysts, and 2 squamous cell carcinoma (lung and oropharynx) lymph node metastases. FNATg of PTC lymph node metastasis was much higher than the reference range of blood serum thyroglobulin, although much lower for the lateral cervical cyst detection threshold. FNAC and FNATg measurement are thought to be mutually complementary in the differential-diagnosis of PTC cystic lymph node metastasis. Conclusion : High concentrations of FNATg in a cystic cervical mass is considered specific to PTC lymph node metastasis, indicating its usefulness in distinguish PTC cystic metastasis from other cystic lesions. Including FNATg measurement with FNAC may thus improve preoperative diagnosis accuracy without additionally stressing subjects with PTC cystic lymph node metastasis.

AB - Background: Combining ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI) and fine-needle aspiration cytology (FNAC) usually results in the best preoperative diagnosis of cervical masses, including neoplasms. This may not be tnie, however, especially in occult papillary thyroid carcinoma (PTC) associated with single cystic cervical lymph node metastasis. We assessed the role of thyroglobulin measurement in FNA fluid (FNATg) in differentially diagnosing cystic cervical mass lesions, including PTC cystic lymph node metastasis. Methods: We reviewed the records of 17 subjects with cervical cystic masses undergoing both FNATg measure ment and surgery. FNA was done under ultrasonographic guidance. We also measured FNATg concentrations from extrathyroid lesions, consisting of cystic cervical lymph node metastases and benign cystic lesions. Results: Pathological diagnosis involved 5 PTC lymph node metastases, 3 lateral cervical cysts, 7 thyroglossal duct cysts, and 2 squamous cell carcinoma (lung and oropharynx) lymph node metastases. FNATg of PTC lymph node metastasis was much higher than the reference range of blood serum thyroglobulin, although much lower for the lateral cervical cyst detection threshold. FNAC and FNATg measurement are thought to be mutually complementary in the differential-diagnosis of PTC cystic lymph node metastasis. Conclusion : High concentrations of FNATg in a cystic cervical mass is considered specific to PTC lymph node metastasis, indicating its usefulness in distinguish PTC cystic metastasis from other cystic lesions. Including FNATg measurement with FNAC may thus improve preoperative diagnosis accuracy without additionally stressing subjects with PTC cystic lymph node metastasis.

KW - Cervical lymph node metastases

KW - Cystic cervical lesion fine-needle aspiration cytology (FNAC)

KW - Papillary thyroid carcinoma

KW - Thyroglobulin

UR - http://www.scopus.com/inward/record.url?scp=84856462684&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856462684&partnerID=8YFLogxK

U2 - 10.3950/jibiinkoka.114.912

DO - 10.3950/jibiinkoka.114.912

M3 - Article

C2 - 22352010

AN - SCOPUS:84856462684

VL - 114

SP - 912

EP - 916

JO - Journal of Otolaryngology of Japan

JF - Journal of Otolaryngology of Japan

SN - 0030-6622

IS - 12

ER -