Thyroid carcinoma: genetics, diagnosis, clinical features, and surgical treatment

Hiroshi Takami, Yoshifumi Ikeda, Gengo Tajima, Shigenao Kan, Kaori Kameyama

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The genes implicated in thyroid carcinoma can be categorized as oncogenes or tumor-suppressor genes. The RET oncogene has well-established roles in the development of both medullary and papillary thyroid carcinoma (PTC). Genetic testing for the germline RET mutation is commonly performed, and prophylactic thyroidectomy is carried out at an early stage. The demonstration of a RET rearrangement in a PTC patient may be prognostic factor. TSH-R and Gs alpha are associated with the development of toxic thyroid adenoma (AFTN). The ras oncogene is implicated in the early stages of development of several tumor types. In conclusion, germline screening for RET mutations is now commonly undertaken in patients with medullary thyroid carcinoma.

Original languageEnglish
Pages (from-to)492-494
Number of pages3
JournalNippon Geka Gakkai zasshi
Volume103
Issue number6
Publication statusPublished - 2002
Externally publishedYes

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Oncogenes
Thyroid Neoplasms
ras Genes
Germ-Line Mutation
Poisons
Thyroidectomy
Genetic Testing
Tumor Suppressor Genes
Mutation
Therapeutics
Genes
Neoplasms
Medullary Thyroid cancer
Papillary Thyroid cancer

Cite this

Thyroid carcinoma : genetics, diagnosis, clinical features, and surgical treatment. / Takami, Hiroshi; Ikeda, Yoshifumi; Tajima, Gengo; Kan, Shigenao; Kameyama, Kaori.

In: Nippon Geka Gakkai zasshi, Vol. 103, No. 6, 2002, p. 492-494.

Research output: Contribution to journalArticle

Takami, H, Ikeda, Y, Tajima, G, Kan, S & Kameyama, K 2002, 'Thyroid carcinoma: genetics, diagnosis, clinical features, and surgical treatment', Nippon Geka Gakkai zasshi, vol. 103, no. 6, pp. 492-494.
Takami, Hiroshi ; Ikeda, Yoshifumi ; Tajima, Gengo ; Kan, Shigenao ; Kameyama, Kaori. / Thyroid carcinoma : genetics, diagnosis, clinical features, and surgical treatment. In: Nippon Geka Gakkai zasshi. 2002 ; Vol. 103, No. 6. pp. 492-494.
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