Thyrotropin-producing microadenoma associated with pituitary resistance to thyroid hormone

Kenji Watanabe, Toru Kameya, Akira Yamauchi, Naohito Yamamoto, Akira Kuwayama, Izumi Takei, Hiroshi Maruyama, Takao Saruta

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A 21-yr-old female with hyperthyroidism is described. Though her serum-free T3 was 17.8 pmol/L and free T4 was 60.2 pmol/L, TSH was as high as 10.7 mU/L. TRH stimulated an increase in TSH from 10.7-91.7 mU/L. T3 administration in gradually increasing doses of 100, 200, and 400 mg/day resulted in gradual reduction in serum TSH. Cranial computed tomography and magnetic resonance imaging revealed a microadenoma of the pituitary gland. Histology of the surgical specimen showed a TSH-producing adenoma with TSH cell cluster islets and decreased numbers of TSH cells in the nonneoplastic pituitary. Cultured cells from the adenoma secreted TSH spontaneously and in response to TRH. This TRH-stimulated TSH secretion was suppressed by T3 in a dose-dependent manner. One year postoperatively, neither residual tumor nor recurrence were seen by computed tomography and magnetic resonance imaging. However TSH, as well as free T3 or T4, was still high and overresponsive to TRH.

Original languageEnglish
Pages (from-to)1025-1030
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume76
Issue number4
Publication statusPublished - 1993 Apr

Fingerprint

Thyroid Hormone Resistance Syndrome
Thyrotrophs
Thyrotropin
Magnetic resonance
Thyroid Hormones
Adenoma
Tomography
Magnetic Resonance Imaging
Imaging techniques
Histology
Residual Neoplasm
Pituitary Gland
Hyperthyroidism
Serum
Tumors
Cultured Cells
Cells
Recurrence

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Watanabe, K., Kameya, T., Yamauchi, A., Yamamoto, N., Kuwayama, A., Takei, I., ... Saruta, T. (1993). Thyrotropin-producing microadenoma associated with pituitary resistance to thyroid hormone. Journal of Clinical Endocrinology and Metabolism, 76(4), 1025-1030.

Thyrotropin-producing microadenoma associated with pituitary resistance to thyroid hormone. / Watanabe, Kenji; Kameya, Toru; Yamauchi, Akira; Yamamoto, Naohito; Kuwayama, Akira; Takei, Izumi; Maruyama, Hiroshi; Saruta, Takao.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 76, No. 4, 04.1993, p. 1025-1030.

Research output: Contribution to journalArticle

Watanabe, K, Kameya, T, Yamauchi, A, Yamamoto, N, Kuwayama, A, Takei, I, Maruyama, H & Saruta, T 1993, 'Thyrotropin-producing microadenoma associated with pituitary resistance to thyroid hormone', Journal of Clinical Endocrinology and Metabolism, vol. 76, no. 4, pp. 1025-1030.
Watanabe K, Kameya T, Yamauchi A, Yamamoto N, Kuwayama A, Takei I et al. Thyrotropin-producing microadenoma associated with pituitary resistance to thyroid hormone. Journal of Clinical Endocrinology and Metabolism. 1993 Apr;76(4):1025-1030.
Watanabe, Kenji ; Kameya, Toru ; Yamauchi, Akira ; Yamamoto, Naohito ; Kuwayama, Akira ; Takei, Izumi ; Maruyama, Hiroshi ; Saruta, Takao. / Thyrotropin-producing microadenoma associated with pituitary resistance to thyroid hormone. In: Journal of Clinical Endocrinology and Metabolism. 1993 ; Vol. 76, No. 4. pp. 1025-1030.
@article{4a75de697c024299a801200a6df72b26,
title = "Thyrotropin-producing microadenoma associated with pituitary resistance to thyroid hormone",
abstract = "A 21-yr-old female with hyperthyroidism is described. Though her serum-free T3 was 17.8 pmol/L and free T4 was 60.2 pmol/L, TSH was as high as 10.7 mU/L. TRH stimulated an increase in TSH from 10.7-91.7 mU/L. T3 administration in gradually increasing doses of 100, 200, and 400 mg/day resulted in gradual reduction in serum TSH. Cranial computed tomography and magnetic resonance imaging revealed a microadenoma of the pituitary gland. Histology of the surgical specimen showed a TSH-producing adenoma with TSH cell cluster islets and decreased numbers of TSH cells in the nonneoplastic pituitary. Cultured cells from the adenoma secreted TSH spontaneously and in response to TRH. This TRH-stimulated TSH secretion was suppressed by T3 in a dose-dependent manner. One year postoperatively, neither residual tumor nor recurrence were seen by computed tomography and magnetic resonance imaging. However TSH, as well as free T3 or T4, was still high and overresponsive to TRH.",
author = "Kenji Watanabe and Toru Kameya and Akira Yamauchi and Naohito Yamamoto and Akira Kuwayama and Izumi Takei and Hiroshi Maruyama and Takao Saruta",
year = "1993",
month = "4",
language = "English",
volume = "76",
pages = "1025--1030",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "4",

}

TY - JOUR

T1 - Thyrotropin-producing microadenoma associated with pituitary resistance to thyroid hormone

AU - Watanabe, Kenji

AU - Kameya, Toru

AU - Yamauchi, Akira

AU - Yamamoto, Naohito

AU - Kuwayama, Akira

AU - Takei, Izumi

AU - Maruyama, Hiroshi

AU - Saruta, Takao

PY - 1993/4

Y1 - 1993/4

N2 - A 21-yr-old female with hyperthyroidism is described. Though her serum-free T3 was 17.8 pmol/L and free T4 was 60.2 pmol/L, TSH was as high as 10.7 mU/L. TRH stimulated an increase in TSH from 10.7-91.7 mU/L. T3 administration in gradually increasing doses of 100, 200, and 400 mg/day resulted in gradual reduction in serum TSH. Cranial computed tomography and magnetic resonance imaging revealed a microadenoma of the pituitary gland. Histology of the surgical specimen showed a TSH-producing adenoma with TSH cell cluster islets and decreased numbers of TSH cells in the nonneoplastic pituitary. Cultured cells from the adenoma secreted TSH spontaneously and in response to TRH. This TRH-stimulated TSH secretion was suppressed by T3 in a dose-dependent manner. One year postoperatively, neither residual tumor nor recurrence were seen by computed tomography and magnetic resonance imaging. However TSH, as well as free T3 or T4, was still high and overresponsive to TRH.

AB - A 21-yr-old female with hyperthyroidism is described. Though her serum-free T3 was 17.8 pmol/L and free T4 was 60.2 pmol/L, TSH was as high as 10.7 mU/L. TRH stimulated an increase in TSH from 10.7-91.7 mU/L. T3 administration in gradually increasing doses of 100, 200, and 400 mg/day resulted in gradual reduction in serum TSH. Cranial computed tomography and magnetic resonance imaging revealed a microadenoma of the pituitary gland. Histology of the surgical specimen showed a TSH-producing adenoma with TSH cell cluster islets and decreased numbers of TSH cells in the nonneoplastic pituitary. Cultured cells from the adenoma secreted TSH spontaneously and in response to TRH. This TRH-stimulated TSH secretion was suppressed by T3 in a dose-dependent manner. One year postoperatively, neither residual tumor nor recurrence were seen by computed tomography and magnetic resonance imaging. However TSH, as well as free T3 or T4, was still high and overresponsive to TRH.

UR - http://www.scopus.com/inward/record.url?scp=0027503346&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027503346&partnerID=8YFLogxK

M3 - Article

C2 - 8473377

AN - SCOPUS:0027503346

VL - 76

SP - 1025

EP - 1030

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 4

ER -