Time course of the liver enhancement by a novel MR contrast agent 'AMI- 25'

Akihiro Tanimoto, Y. Yuasa, M. Izutsu, Y. Sato, S. Ohkawa, K. Hiramatsu

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Abstract

Superparamagnetic iron oxide (SPIO; AMI-25 from Eiken Chemical Co.) have been known to offer excellent tumor-liver contrast in liver MR imaging by reducing the signal intensity only of the liver. To investigate the duration of liver signal decrease caused by AMI-25, 15 patients underwent MR imaging three times; before, 1 hour after, and at the different elapsed time after the drug administration (4-9 hours, 22-26 hours, and 47-49 hours). The liver darkness and the contribution of the drug to hepatic tumor detection were subjectively ranked and liver signal-to-noise ratio (SNR) and tumor-liver contrast-to-noise ratio (CNR) were obtained by the region of interest, and compared among groups with different elapsed time. Both liver darkness and SNR were maintained up to 4-9 hours after the drug administration, and both the contribution to the tumor detection and CNR showed the similar results. Our results show that effect of AMI-25 could be maintained at least several hours after the drug administration, lasting longer than previously thought.

Original languageEnglish
Pages (from-to)713-724
Number of pages12
JournalJapanese Pharmacology and Therapeutics
Volume22
Issue number1
Publication statusPublished - 1994

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ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Tanimoto, A., Yuasa, Y., Izutsu, M., Sato, Y., Ohkawa, S., & Hiramatsu, K. (1994). Time course of the liver enhancement by a novel MR contrast agent 'AMI- 25'. Japanese Pharmacology and Therapeutics, 22(1), 713-724.