Time-domain diffuse optical tomography with lp sparsity regularization for thyroid cancer imaging

Shinpei Okawa, Tetsuya Mimura, Hiroyuki Fujii, Hiroshi Kawaguchi, Yukari Tanikawa, Manabu Machida, Eiji Okada, Yoko Hoshi

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Diffuse optical tomography (DOT) images the distribution of the optical properties, such as the absorption and scattering coefficients, via the image reconstruction from the light intensities measured at the surface of the biological medium. The changes in the optical properties reflect the conditions of the tissues. Therefore, DOT image can provide the information which is not obtained from the other modalities and is useful for medical diagnoses. In this study, the application of the DOT to thyroid cancer diagnosis was investigated. The ultrasound technique is usually carried out for the thyroid cancer diagnosis. It is, however, difficult to distinguish follicular carcinoma from adenoma of thyroid. The optical properties may be helpful for the diagnosis. The image reconstruction algorithm employing the regularization minimizing lp-norm (0 < p < 2) of the reconstructed image was developed. The image was reconstructed from the time-resolved measurement data. The numerical simulations of the image reconstruction were tried. The numerical simulation demonstrated that the developed algorithm was able to image the changes in the optical properties in the medium. Additionally, the image reconstruction of the numerical neck phantom was simulated. The thyroid cancer region was reconstructed successfully. It was demonstrated that the developed algorithm had the possibility to image thyroid cancer.

Original languageEnglish
Title of host publicationEuropean Conference on Biomedical Optics, ECBO_2019
PublisherOSA - The Optical Society
ISBN (Electronic)9781557528209
Publication statusPublished - 2019
EventEuropean Conference on Biomedical Optics, ECBO_2019 - Munich, Netherlands
Duration: 2019 Jun 232019 Jun 25

Publication series

NameOptics InfoBase Conference Papers
VolumePart F142-ECBO 2019


ConferenceEuropean Conference on Biomedical Optics, ECBO_2019


  • Diffuse optical tomography
  • Image reconstruction
  • Thyroid cancer

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials


Dive into the research topics of 'Time-domain diffuse optical tomography with l<sub>p</sub> sparsity regularization for thyroid cancer imaging'. Together they form a unique fingerprint.

Cite this