Timing of Adjunctive Therapy in the Treatment of Depression

A Chart Review

R. Tarumi, T. Suzuki, H. Tani, R. Den, N. Sawada, H. Sakurai, C. Tsutsumi-Ozawa, A. Ohtani, Masaru Mimura, Hiroyuki Uchida

Research output: Contribution to journalArticle

Abstract

Introduction: The objective of this study was to examine the evolution of antidepressant switch and adjunctive therapy. Methods: This chart review was conducted at 6 primary psychiatric clinics or hospitals, in Tokyo, Japan. A chart review of longitudinal prescriptions was conducted regarding 633 outpatients with major depressive disorder for up to 2 years after their first visit. Patients who had already received antidepressants prior to the visit were excluded. Results: 22.6% (N=143) of the patients completed or continued the outpatient treatment over the 2 years while 27 (4.3%), 23 (3.6%), and 439 (69.4%) patients discontinued it due to hospitalization, referral to another clinic, and loss to follow-up, respectively. A total of 597 episodes of antidepressant treatment were identified. Among them, 482 episodes (80.7%) were associated with the suggested dose ranges while antidepressant drugs were under-dosed in 19.3% (N=115) of the episodes. 50 patients (7.9%) received adjunctive therapy; it was employed after a median of only one antidepressant had been tried. Conclusion: Psychiatrists may be hasty in prescribing an adjunctive therapy in the treatment of depression.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalPharmacopsychiatry
Volume47
Issue number7
DOIs
Publication statusPublished - 2014 Oct 16

Fingerprint

Antidepressive Agents
Depression
Psychiatry
Outpatients
Therapeutics
Tokyo
Major Depressive Disorder
Prescriptions
Japan
Hospitalization
Referral and Consultation

Keywords

  • adjunctive therapy
  • antidepressants
  • depression

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health

Cite this

Timing of Adjunctive Therapy in the Treatment of Depression : A Chart Review. / Tarumi, R.; Suzuki, T.; Tani, H.; Den, R.; Sawada, N.; Sakurai, H.; Tsutsumi-Ozawa, C.; Ohtani, A.; Mimura, Masaru; Uchida, Hiroyuki.

In: Pharmacopsychiatry, Vol. 47, No. 7, 16.10.2014, p. 259-262.

Research output: Contribution to journalArticle

Tarumi, R, Suzuki, T, Tani, H, Den, R, Sawada, N, Sakurai, H, Tsutsumi-Ozawa, C, Ohtani, A, Mimura, M & Uchida, H 2014, 'Timing of Adjunctive Therapy in the Treatment of Depression: A Chart Review', Pharmacopsychiatry, vol. 47, no. 7, pp. 259-262. https://doi.org/10.1055/s-0034-1387784
Tarumi R, Suzuki T, Tani H, Den R, Sawada N, Sakurai H et al. Timing of Adjunctive Therapy in the Treatment of Depression: A Chart Review. Pharmacopsychiatry. 2014 Oct 16;47(7):259-262. https://doi.org/10.1055/s-0034-1387784
Tarumi, R. ; Suzuki, T. ; Tani, H. ; Den, R. ; Sawada, N. ; Sakurai, H. ; Tsutsumi-Ozawa, C. ; Ohtani, A. ; Mimura, Masaru ; Uchida, Hiroyuki. / Timing of Adjunctive Therapy in the Treatment of Depression : A Chart Review. In: Pharmacopsychiatry. 2014 ; Vol. 47, No. 7. pp. 259-262.
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