Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation

Tomohisa Sujino, Mariya London, David P.Hoytema Van Konijnenburg, Tomiko Rendon, Thorsten Buch, Hernandez M. Silva, Juan J. Lafaille, Bernardo S. Reis, Daniel Mucida

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Foxp3+ regulatory T cells in peripheral tissues (pTregs) are instrumental in limiting inflammatory responses to nonself antigens. Within the intestine, pTregs are located primarily in the lamina propria, whereas intraepithelial CD4+ T cells (CD4IELs), which also exhibit anti-inflammatory properties and depend on similar environmental cues, reside in the epithelium. Using intravital microscopy, we show distinct cell dynamics of intestinal Tregs and CD4IELs. Upon migration to the epithelium,Tregs lose Foxp3 and convert to CD4IELs in a microbiota-dependent manner, an effect attributed to the loss of the transcription factor ThPOK. Finally, we demonstrate that pTregs and CD4IELs perform complementary roles in the regulation of intestinal inflammation. These results reveal intratissue specialization of anti-inflammatory T cells shaped by discrete niches of the intestine.

Original languageEnglish
Pages (from-to)1581-1586
Number of pages6
JournalScience
Volume352
Issue number6293
DOIs
Publication statusPublished - 2016 Jun 24
Externally publishedYes

Fingerprint

Intestines
Anti-Inflammatory Agents
Epithelium
Inflammation
T-Lymphocytes
Microbiota
Regulatory T-Lymphocytes
Cues
Mucous Membrane
Transcription Factors
Antigens
Thomsen-Friedenreich antibodies
Intravital Microscopy

ASJC Scopus subject areas

  • General

Cite this

Sujino, T., London, M., Van Konijnenburg, D. P. H., Rendon, T., Buch, T., Silva, H. M., ... Mucida, D. (2016). Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation. Science, 352(6293), 1581-1586. https://doi.org/10.1126/science.aaf3892

Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation. / Sujino, Tomohisa; London, Mariya; Van Konijnenburg, David P.Hoytema; Rendon, Tomiko; Buch, Thorsten; Silva, Hernandez M.; Lafaille, Juan J.; Reis, Bernardo S.; Mucida, Daniel.

In: Science, Vol. 352, No. 6293, 24.06.2016, p. 1581-1586.

Research output: Contribution to journalArticle

Sujino, T, London, M, Van Konijnenburg, DPH, Rendon, T, Buch, T, Silva, HM, Lafaille, JJ, Reis, BS & Mucida, D 2016, 'Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation', Science, vol. 352, no. 6293, pp. 1581-1586. https://doi.org/10.1126/science.aaf3892
Sujino T, London M, Van Konijnenburg DPH, Rendon T, Buch T, Silva HM et al. Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation. Science. 2016 Jun 24;352(6293):1581-1586. https://doi.org/10.1126/science.aaf3892
Sujino, Tomohisa ; London, Mariya ; Van Konijnenburg, David P.Hoytema ; Rendon, Tomiko ; Buch, Thorsten ; Silva, Hernandez M. ; Lafaille, Juan J. ; Reis, Bernardo S. ; Mucida, Daniel. / Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation. In: Science. 2016 ; Vol. 352, No. 6293. pp. 1581-1586.
@article{c8ca70db63f04bfe97d5e0aad4f5b319,
title = "Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation",
abstract = "Foxp3+ regulatory T cells in peripheral tissues (pTregs) are instrumental in limiting inflammatory responses to nonself antigens. Within the intestine, pTregs are located primarily in the lamina propria, whereas intraepithelial CD4+ T cells (CD4IELs), which also exhibit anti-inflammatory properties and depend on similar environmental cues, reside in the epithelium. Using intravital microscopy, we show distinct cell dynamics of intestinal Tregs and CD4IELs. Upon migration to the epithelium,Tregs lose Foxp3 and convert to CD4IELs in a microbiota-dependent manner, an effect attributed to the loss of the transcription factor ThPOK. Finally, we demonstrate that pTregs and CD4IELs perform complementary roles in the regulation of intestinal inflammation. These results reveal intratissue specialization of anti-inflammatory T cells shaped by discrete niches of the intestine.",
author = "Tomohisa Sujino and Mariya London and {Van Konijnenburg}, {David P.Hoytema} and Tomiko Rendon and Thorsten Buch and Silva, {Hernandez M.} and Lafaille, {Juan J.} and Reis, {Bernardo S.} and Daniel Mucida",
year = "2016",
month = "6",
day = "24",
doi = "10.1126/science.aaf3892",
language = "English",
volume = "352",
pages = "1581--1586",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6293",

}

TY - JOUR

T1 - Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation

AU - Sujino, Tomohisa

AU - London, Mariya

AU - Van Konijnenburg, David P.Hoytema

AU - Rendon, Tomiko

AU - Buch, Thorsten

AU - Silva, Hernandez M.

AU - Lafaille, Juan J.

AU - Reis, Bernardo S.

AU - Mucida, Daniel

PY - 2016/6/24

Y1 - 2016/6/24

N2 - Foxp3+ regulatory T cells in peripheral tissues (pTregs) are instrumental in limiting inflammatory responses to nonself antigens. Within the intestine, pTregs are located primarily in the lamina propria, whereas intraepithelial CD4+ T cells (CD4IELs), which also exhibit anti-inflammatory properties and depend on similar environmental cues, reside in the epithelium. Using intravital microscopy, we show distinct cell dynamics of intestinal Tregs and CD4IELs. Upon migration to the epithelium,Tregs lose Foxp3 and convert to CD4IELs in a microbiota-dependent manner, an effect attributed to the loss of the transcription factor ThPOK. Finally, we demonstrate that pTregs and CD4IELs perform complementary roles in the regulation of intestinal inflammation. These results reveal intratissue specialization of anti-inflammatory T cells shaped by discrete niches of the intestine.

AB - Foxp3+ regulatory T cells in peripheral tissues (pTregs) are instrumental in limiting inflammatory responses to nonself antigens. Within the intestine, pTregs are located primarily in the lamina propria, whereas intraepithelial CD4+ T cells (CD4IELs), which also exhibit anti-inflammatory properties and depend on similar environmental cues, reside in the epithelium. Using intravital microscopy, we show distinct cell dynamics of intestinal Tregs and CD4IELs. Upon migration to the epithelium,Tregs lose Foxp3 and convert to CD4IELs in a microbiota-dependent manner, an effect attributed to the loss of the transcription factor ThPOK. Finally, we demonstrate that pTregs and CD4IELs perform complementary roles in the regulation of intestinal inflammation. These results reveal intratissue specialization of anti-inflammatory T cells shaped by discrete niches of the intestine.

UR - http://www.scopus.com/inward/record.url?scp=84974536519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84974536519&partnerID=8YFLogxK

U2 - 10.1126/science.aaf3892

DO - 10.1126/science.aaf3892

M3 - Article

C2 - 27256884

AN - SCOPUS:84974536519

VL - 352

SP - 1581

EP - 1586

JO - Science

JF - Science

SN - 0036-8075

IS - 6293

ER -