Tissue-specific expression and mapping of the Cox7ah gene in mouse

Saied A. Jaradat, Minoru Ko, Lawrence I. Grossman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We have isolated and examined the gene for the heart isoform of cytochrome c oxidase subunit VIIa (COX VIIa-H) in mouse, an isoform gene previously thought to be lacking in rodents. Interspecies amino acid comparisons indicate that mouse COX VIIa-H protein displays 82.5 and 70.9% identity with the bovine and human heart isoforms of COX VIIa, but only 53.7% identity with the paralogous mouse liver isoform (COX VIIa-L). Expression in adult mouse tissues is limited to heart and skeletal muscle, as found in other species. In the early mouse embryo, Cox7al was the exclusive isoform expressed and Cox7ah mRNA was not detectable until day 17 postcoitum. That the mouse Cox7ah gene characterized in this study is orthologous to the human COX7AH gene was also suggested by its mapping to mouse chromosome 7, to a conserved region syntenic with the human chromosome location of COX7AH, 19q13.1. As a result, all three COX heart isoform genes in mouse group to chromosome 7. Interestingly, mapping of the mouse Cox7al to chromosome 9 suggests a new syntenic region between the mouse and the human genomes.

Original languageEnglish
Pages (from-to)363-370
Number of pages8
JournalGenomics
Volume49
Issue number3
DOIs
Publication statusPublished - 1998 May 1
Externally publishedYes

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Chromosome Mapping
Protein Isoforms
Chromosomes, Human, Pair 7
Genes
Chromosomes, Human, Pair 9
Human Chromosomes
Human Genome
Electron Transport Complex IV
Rodentia
Myocardium
Skeletal Muscle
Embryonic Structures
Amino Acids
Messenger RNA

ASJC Scopus subject areas

  • Genetics

Cite this

Tissue-specific expression and mapping of the Cox7ah gene in mouse. / Jaradat, Saied A.; Ko, Minoru; Grossman, Lawrence I.

In: Genomics, Vol. 49, No. 3, 01.05.1998, p. 363-370.

Research output: Contribution to journalArticle

Jaradat, Saied A. ; Ko, Minoru ; Grossman, Lawrence I. / Tissue-specific expression and mapping of the Cox7ah gene in mouse. In: Genomics. 1998 ; Vol. 49, No. 3. pp. 363-370.
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