Tissue-specific stem cells in the myometrium and tumor-initiating cells in Leiomyoma

Masanori Ono, Serdar E. Bulun, Tetsuo Maruyama

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Tissue-specific (or somatic) stem cells constitute a subset of cells residing in normal adult tissues. By undergoing asymmetric division, they retain their ability to self-renew while producing daughter cells that go on to differentiate and play a role in tissue regeneration and repair. The human uterus consists primarily of endometrium and myometrium (the smooth muscle layer) that rapidly enlarges through its tremendous regenerative and remodeling capacity to accommodate the developing fetus. Such uterine enlargement and remodeling can take place repeatedly and cyclically over the course of a woman's reproductive life. These unique properties of the uterus suggest the existence of endometrial and myometrial stem cell systems. In addition, like somatic cells, tumor stem cells or tumorinitiating cells, a subset of cells within a tumor, retain the ability to reconstitute tumors. Uterine smooth muscle cells are thought to be the origin of leiomyomas that are the most common type of gynecologic tumor. Recent work has identified, isolated, and characterized putative stem/progenitor cells in the myometrium and in leiomyomas. Here, we review current studies of myometrial and leiomyoma stem/progenitor cells and provide a new paradigm for understanding myometrial physiology and pathology and how these cells might contribute to uterine remodeling during pregnancy and the formation of leiomyomas. The role of the WNT/CTNNB1 pathway in the pathogenesis of leiomyoma is also discussed.

Original languageEnglish
Article number149
JournalBiology of Reproduction
Volume91
Issue number6
DOIs
Publication statusPublished - 2014 Dec 1

Fingerprint

Neoplastic Stem Cells
Myometrium
Leiomyoma
Stem Cells
Uterus
Cell Physiological Phenomena
Neoplasms
Adult Stem Cells
Endometrium
Smooth Muscle Myocytes
Smooth Muscle
Regeneration
Fetus
Pathology
Pregnancy

Keywords

  • Leiomyoma
  • Myometrium
  • Pregnancy
  • Regeneration
  • Tissue-specific stem cells
  • Tumor-initiating cells

ASJC Scopus subject areas

  • Cell Biology

Cite this

Tissue-specific stem cells in the myometrium and tumor-initiating cells in Leiomyoma. / Ono, Masanori; Bulun, Serdar E.; Maruyama, Tetsuo.

In: Biology of Reproduction, Vol. 91, No. 6, 149, 01.12.2014.

Research output: Contribution to journalArticle

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