TKI dasatinib monotherapy for a patient with Ph-like ALL bearing ATF7IP/PDGFRB translocation

Kenichiro Kobayashi; Naoyuki Miyagawa; Kazumasa Mitsui; Masaki Matsuoka; Yasuko Kojima; Hiroyuki Takahashi; Kaori Ootsubo; Junichi Nagai; Hitomi Ueno; Takeshi Ishibashi; Sara Sultana; Yoko Okada; Shingo Akimoto; Hajime Okita; Kimikazu Matsumoto; Hiroaki Goto; Nobutaka Kiyokawa; Akira Ohara

doi:10.1002/pbc.25327

TKI dasatinib monotherapy for a patient with Ph-like ALL bearing ATF7IP/PDGFRB translocation

Kenichiro Kobayashi, Naoyuki Miyagawa, Kazumasa Mitsui, Masaki Matsuoka, Yasuko Kojima, Hiroyuki Takahashi, Kaori Ootsubo, Junichi Nagai, Hitomi Ueno, Takeshi Ishibashi, Sara Sultana, Yoko Okada, Shingo Akimoto, Hajime Okita, Kimikazu Matsumoto, Hiroaki Goto, Nobutaka Kiyokawa, Akira Ohara

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50 Citations (Scopus)

Abstract

We report a 10-year-old male with relapsing Ph-like acute lymphoblastic leukemia (ALL) bearing ATF7IP/PDGFRB translocation. He was refractory to conventional therapy, and was finally treated with single-agent second-generation TKI dasatinib. The therapeutic response was prompt, with the disappearance of minimum residual disease (MRD) based on genomic PCR analysis within 3 months, and he has maintained complete molecular remission for 12 months. This case report describes an early-phase response to TKI monotherapy on Ph-like ALL, and technical tips for MRD monitoring on long-term follow-up.

Original language	English
Pages (from-to)	1058-1060
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	62
Issue number	6
DOIs	https://doi.org/10.1002/pbc.25327
Publication status	Published - 2015 Jun 1
Externally published	Yes

Keywords

Genomic PCR
MRD
PDGFRB fusion
Ph-like ALL
TKI

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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Kobayashi, K., Miyagawa, N., Mitsui, K., Matsuoka, M., Kojima, Y., Takahashi, H., Ootsubo, K., Nagai, J., Ueno, H., Ishibashi, T., Sultana, S., Okada, Y., Akimoto, S., Okita, H., Matsumoto, K., Goto, H., Kiyokawa, N., & Ohara, A. (2015). TKI dasatinib monotherapy for a patient with Ph-like ALL bearing ATF7IP/PDGFRB translocation. Pediatric Blood and Cancer, 62(6), 1058-1060. https://doi.org/10.1002/pbc.25327

Kobayashi, K, Miyagawa, N, Mitsui, K, Matsuoka, M, Kojima, Y, Takahashi, H, Ootsubo, K, Nagai, J, Ueno, H, Ishibashi, T, Sultana, S, Okada, Y, Akimoto, S, Okita, H, Matsumoto, K, Goto, H, Kiyokawa, N & Ohara, A 2015, 'TKI dasatinib monotherapy for a patient with Ph-like ALL bearing ATF7IP/PDGFRB translocation', Pediatric Blood and Cancer, vol. 62, no. 6, pp. 1058-1060. https://doi.org/10.1002/pbc.25327

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abstract = "We report a 10-year-old male with relapsing Ph-like acute lymphoblastic leukemia (ALL) bearing ATF7IP/PDGFRB translocation. He was refractory to conventional therapy, and was finally treated with single-agent second-generation TKI dasatinib. The therapeutic response was prompt, with the disappearance of minimum residual disease (MRD) based on genomic PCR analysis within 3 months, and he has maintained complete molecular remission for 12 months. This case report describes an early-phase response to TKI monotherapy on Ph-like ALL, and technical tips for MRD monitoring on long-term follow-up.",

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AU - Kobayashi, Kenichiro

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AU - Mitsui, Kazumasa

AU - Matsuoka, Masaki

AU - Kojima, Yasuko

AU - Takahashi, Hiroyuki

AU - Ootsubo, Kaori

AU - Nagai, Junichi

AU - Ueno, Hitomi

AU - Ishibashi, Takeshi

AU - Sultana, Sara

AU - Okada, Yoko

AU - Akimoto, Shingo

AU - Okita, Hajime

AU - Matsumoto, Kimikazu

AU - Goto, Hiroaki

AU - Kiyokawa, Nobutaka

AU - Ohara, Akira

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AB - We report a 10-year-old male with relapsing Ph-like acute lymphoblastic leukemia (ALL) bearing ATF7IP/PDGFRB translocation. He was refractory to conventional therapy, and was finally treated with single-agent second-generation TKI dasatinib. The therapeutic response was prompt, with the disappearance of minimum residual disease (MRD) based on genomic PCR analysis within 3 months, and he has maintained complete molecular remission for 12 months. This case report describes an early-phase response to TKI monotherapy on Ph-like ALL, and technical tips for MRD monitoring on long-term follow-up.

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KW - TKI

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TKI dasatinib monotherapy for a patient with Ph-like ALL bearing ATF7IP/PDGFRB translocation

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Keywords

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