Tokyo centenarian study 4 apolipoprotein E phenotype in Japanese centenarians living in the Tokyo metropolitan area

N. Hirose, S. Homma, Yasumichi Arai, M. Kawamura, H. Hasegawa, Hiroyuki Ishida, K. Shimizu, Y. Osono, A. Homma, Y. Nakamura

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

To examine the relationship between apolipoprotein E (apoE) phenotype and life span, we measured the frequency of the apoE phenotype and allele in 54 Japanese centenarians who lived in the Tokyo metropolitan area in 1994, 1995, and 1996. The control group consisted of 973 subjects, 883 healthy volunteers who were described previously and 90 healthy people who came to the Keio health consulting center. The apoE phenotypes in the centenarians was 2 E2/E2 (3.7%), 5 E2/E3 (9.3%), 38 E3/E3 (70.4%), and 9 3E/E4 (16.7%). No other phenotype was observed. In the control group, the phenotypes were 2 E2/E2 (0.2%), 57 E2/E3 (5.9%), 712 E3/E3 (73.2%), and 179 E3/E4 (18.4%). The frequency of E2 was higher in the centenarians. The frequencies of the apoE allele in the centenarians and the control subjects were ε2 8.3% vs. 3.5%, ε3 83.3% vs. 85.4%, and ε4 8.3% vs, 10.9%. The frequency of the apoE allele differed significantly between centenarians and control subjects (χ2= 6.84, p=0.033). Levels of serum cholesterol and apolipoprotein B were significantly lower in the E2/E2 + E2/E3 centenarians. Studies of the frequency of the apoE allele in Japanese, French, and Finnish subjects showed that ε2 is more frequent and ε4 is less frequent in centenarians. These data show the apoE phenotype may affect life span: ε2 is positively and ε4 is negatively associated with longevity.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalJapanese Journal of Geriatrics
Volume34
Issue number4
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Apolipoprotein E4
Tokyo
Apolipoproteins E
Phenotype
Alleles
Control Groups
Apolipoproteins B
Healthy Volunteers
Cholesterol
Health
Serum

Keywords

  • ε2
  • ε4
  • Centenarian
  • E2/E2
  • Hypocholesterolemia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tokyo centenarian study 4 apolipoprotein E phenotype in Japanese centenarians living in the Tokyo metropolitan area. / Hirose, N.; Homma, S.; Arai, Yasumichi; Kawamura, M.; Hasegawa, H.; Ishida, Hiroyuki; Shimizu, K.; Osono, Y.; Homma, A.; Nakamura, Y.

In: Japanese Journal of Geriatrics, Vol. 34, No. 4, 1997, p. 267-272.

Research output: Contribution to journalArticle

Hirose, N, Homma, S, Arai, Y, Kawamura, M, Hasegawa, H, Ishida, H, Shimizu, K, Osono, Y, Homma, A & Nakamura, Y 1997, 'Tokyo centenarian study 4 apolipoprotein E phenotype in Japanese centenarians living in the Tokyo metropolitan area', Japanese Journal of Geriatrics, vol. 34, no. 4, pp. 267-272.
Hirose, N. ; Homma, S. ; Arai, Yasumichi ; Kawamura, M. ; Hasegawa, H. ; Ishida, Hiroyuki ; Shimizu, K. ; Osono, Y. ; Homma, A. ; Nakamura, Y. / Tokyo centenarian study 4 apolipoprotein E phenotype in Japanese centenarians living in the Tokyo metropolitan area. In: Japanese Journal of Geriatrics. 1997 ; Vol. 34, No. 4. pp. 267-272.
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AU - Hasegawa, H.

AU - Ishida, Hiroyuki

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AU - Osono, Y.

AU - Homma, A.

AU - Nakamura, Y.

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