TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1

Takuya Terai, Rie Tomiyasu, Tomoe Ota, Tasuku Ueno, Toru Komatsu, Kenjiro Hanaoka, Yasuteru Urano, Tetsuo Nagano

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

TokyoGreen (TG) derivatives were found to be efficient and specific substrates of an important drug-metabolizing enzyme, UDP-glucuronosyltransferase (UGT) 1A1. A rapid, specific, and sensitive assay of the enzyme was achieved simply by monitoring the change in fluorescence intensity. We also designed and developed the first “turn-on” fluorescent probes for UGTs.

Original languageEnglish
Pages (from-to)3101-3103
Number of pages3
JournalChemical Communications
Volume49
Issue number30
DOIs
Publication statusPublished - 2013 Mar 19
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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