TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1

Takuya Terai; Rie Tomiyasu; Tomoe Ota; Tasuku Ueno; Toru Komatsu; Kenjiro Hanaoka; Yasuteru Urano; Tetsuo Nagano

doi:10.1039/c3cc38810g

TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1

Takuya Terai, Rie Tomiyasu, Tomoe Ota, Tasuku Ueno, Toru Komatsu, Kenjiro Hanaoka, Yasuteru Urano, Tetsuo Nagano

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

TokyoGreen (TG) derivatives were found to be efficient and specific substrates of an important drug-metabolizing enzyme, UDP-glucuronosyltransferase (UGT) 1A1. A rapid, specific, and sensitive assay of the enzyme was achieved simply by monitoring the change in fluorescence intensity. We also designed and developed the first “turn-on” fluorescent probes for UGTs.

Original language	English
Pages (from-to)	3101-3103
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	30
DOIs	https://doi.org/10.1039/c3cc38810g
Publication status	Published - 2013 Mar 19
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "TokyoGreen (TG) derivatives were found to be efficient and specific substrates of an important drug-metabolizing enzyme, UDP-glucuronosyltransferase (UGT) 1A1. A rapid, specific, and sensitive assay of the enzyme was achieved simply by monitoring the change in fluorescence intensity. We also designed and developed the first “turn-on” fluorescent probes for UGTs.",

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AU - Terai, Takuya

AU - Tomiyasu, Rie

AU - Ota, Tomoe

AU - Ueno, Tasuku

AU - Komatsu, Toru

AU - Hanaoka, Kenjiro

AU - Urano, Yasuteru

AU - Nagano, Tetsuo

PY - 2013/3/19

Y1 - 2013/3/19

N2 - TokyoGreen (TG) derivatives were found to be efficient and specific substrates of an important drug-metabolizing enzyme, UDP-glucuronosyltransferase (UGT) 1A1. A rapid, specific, and sensitive assay of the enzyme was achieved simply by monitoring the change in fluorescence intensity. We also designed and developed the first “turn-on” fluorescent probes for UGTs.

AB - TokyoGreen (TG) derivatives were found to be efficient and specific substrates of an important drug-metabolizing enzyme, UDP-glucuronosyltransferase (UGT) 1A1. A rapid, specific, and sensitive assay of the enzyme was achieved simply by monitoring the change in fluorescence intensity. We also designed and developed the first “turn-on” fluorescent probes for UGTs.

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TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1

Abstract

ASJC Scopus subject areas

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