Abstract
Toll-like receptor 1 (TLR1) genetic variant (rs5743551, − 7202A > G) has been reported to be associated with susceptibility to various infectious diseases. We retrospectively examined the impact of TLR1 variation on transplant outcomes in a cohort of 320 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. A multivariate analysis showed that the G/G genotype in the recipients and the donors was associated with a significantly lower 3-year transplant-related mortality (TRM). The recipient G/G genotype also resulted in a better 3-year progression-free survival. This study suggests that the recipient and donor TLR1 G/G genotypes are comparably associated with a reduced risk of death that was not related to relapse. Thus, TLR1 genotyping may be useful for selecting the donor, managing patients in a risk-adapted manner, and creating therapeutic strategies to prevent complications after hematopoietic stem cell transplantation.
| Original language | English |
|---|---|
| Pages (from-to) | 60-66 |
| Number of pages | 7 |
| Journal | Transplant Immunology |
| Volume | 38 |
| DOIs | |
| Publication status | Published - 2016 Sep 1 |
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Keywords
- Bone marrow transplantation
- Single nucleotide variation
- TLR1
- Unrelated donor
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Transplantation
Cite this
Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies. / Uchino, Kaori; Mizuno, Shohei; Mizutani, Motonori; Horio, Tomohiro; Hanamura, Ichiro; Espinoza, J. Luis; Matsuo, Keitaro; Onizuka, Makoto; Kashiwase, Koichi; Morishima, Yasuo; Fukuda, Takahiro; Kodera, Yoshihisa; Doki, Noriko; Miyamura, Koichi; Mori, Takehiko; Takami, Akiyoshi.
In: Transplant Immunology, Vol. 38, 01.09.2016, p. 60-66.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies
AU - Uchino, Kaori
AU - Mizuno, Shohei
AU - Mizutani, Motonori
AU - Horio, Tomohiro
AU - Hanamura, Ichiro
AU - Espinoza, J. Luis
AU - Matsuo, Keitaro
AU - Onizuka, Makoto
AU - Kashiwase, Koichi
AU - Morishima, Yasuo
AU - Fukuda, Takahiro
AU - Kodera, Yoshihisa
AU - Doki, Noriko
AU - Miyamura, Koichi
AU - Mori, Takehiko
AU - Takami, Akiyoshi
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Toll-like receptor 1 (TLR1) genetic variant (rs5743551, − 7202A > G) has been reported to be associated with susceptibility to various infectious diseases. We retrospectively examined the impact of TLR1 variation on transplant outcomes in a cohort of 320 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. A multivariate analysis showed that the G/G genotype in the recipients and the donors was associated with a significantly lower 3-year transplant-related mortality (TRM). The recipient G/G genotype also resulted in a better 3-year progression-free survival. This study suggests that the recipient and donor TLR1 G/G genotypes are comparably associated with a reduced risk of death that was not related to relapse. Thus, TLR1 genotyping may be useful for selecting the donor, managing patients in a risk-adapted manner, and creating therapeutic strategies to prevent complications after hematopoietic stem cell transplantation.
AB - Toll-like receptor 1 (TLR1) genetic variant (rs5743551, − 7202A > G) has been reported to be associated with susceptibility to various infectious diseases. We retrospectively examined the impact of TLR1 variation on transplant outcomes in a cohort of 320 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. A multivariate analysis showed that the G/G genotype in the recipients and the donors was associated with a significantly lower 3-year transplant-related mortality (TRM). The recipient G/G genotype also resulted in a better 3-year progression-free survival. This study suggests that the recipient and donor TLR1 G/G genotypes are comparably associated with a reduced risk of death that was not related to relapse. Thus, TLR1 genotyping may be useful for selecting the donor, managing patients in a risk-adapted manner, and creating therapeutic strategies to prevent complications after hematopoietic stem cell transplantation.
KW - Bone marrow transplantation
KW - Single nucleotide variation
KW - TLR1
KW - Unrelated donor
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UR - http://www.scopus.com/inward/citedby.url?scp=84987602230&partnerID=8YFLogxK
U2 - 10.1016/j.trim.2016.06.002
DO - 10.1016/j.trim.2016.06.002
M3 - Article
C2 - 27369862
AN - SCOPUS:84987602230
VL - 38
SP - 60
EP - 66
JO - Transplant Immunology
JF - Transplant Immunology
SN - 0966-3274
ER -