Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies

Kaori Uchino; Shohei Mizuno; Motonori Mizutani; Tomohiro Horio; Ichiro Hanamura; J. Luis Espinoza; Keitaro Matsuo; Makoto Onizuka; Koichi Kashiwase; Yasuo Morishima; Takahiro Fukuda; Yoshihisa Kodera; Noriko Doki; Koichi Miyamura; Takehiko Mori Takehiko Mori; Akiyoshi Takami

doi:10.1016/j.trim.2016.06.002

Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies

Kaori Uchino, Shohei Mizuno, Motonori Mizutani, Tomohiro Horio, Ichiro Hanamura, J. Luis Espinoza, Keitaro Matsuo, Makoto Onizuka, Koichi Kashiwase, Yasuo Morishima, Takahiro Fukuda, Yoshihisa Kodera, Noriko Doki, Koichi Miyamura, Takehiko Mori Takehiko Mori, Akiyoshi Takami

Department of Internal Medicine (Hematology)

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

Toll-like receptor 1 (TLR1) genetic variant (rs5743551, − 7202A > G) has been reported to be associated with susceptibility to various infectious diseases. We retrospectively examined the impact of TLR1 variation on transplant outcomes in a cohort of 320 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. A multivariate analysis showed that the G/G genotype in the recipients and the donors was associated with a significantly lower 3-year transplant-related mortality (TRM). The recipient G/G genotype also resulted in a better 3-year progression-free survival. This study suggests that the recipient and donor TLR1 G/G genotypes are comparably associated with a reduced risk of death that was not related to relapse. Thus, TLR1 genotyping may be useful for selecting the donor, managing patients in a risk-adapted manner, and creating therapeutic strategies to prevent complications after hematopoietic stem cell transplantation.

Original language	English
Pages (from-to)	60-66
Number of pages	7
Journal	Transplant Immunology
Volume	38
DOIs	https://doi.org/10.1016/j.trim.2016.06.002
Publication status	Published - 2016 Sep 1

Keywords

Bone marrow transplantation
Single nucleotide variation
TLR1
Unrelated donor

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Transplantation

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Uchino, K., Mizuno, S., Mizutani, M., Horio, T., Hanamura, I., Espinoza, J. L., Matsuo, K., Onizuka, M., Kashiwase, K., Morishima, Y., Fukuda, T., Kodera, Y., Doki, N., Miyamura, K., Mori, T. M. T., & Takami, A. (2016). Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies. Transplant Immunology, 38, 60-66. https://doi.org/10.1016/j.trim.2016.06.002

Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies. / Uchino, Kaori; Mizuno, Shohei; Mizutani, Motonori; Horio, Tomohiro; Hanamura, Ichiro; Espinoza, J. Luis; Matsuo, Keitaro; Onizuka, Makoto; Kashiwase, Koichi; Morishima, Yasuo; Fukuda, Takahiro; Kodera, Yoshihisa; Doki, Noriko; Miyamura, Koichi; Mori, Takehiko Mori Takehiko; Takami, Akiyoshi.

In: Transplant Immunology, Vol. 38, 01.09.2016, p. 60-66.

Research output: Contribution to journal › Article

Uchino, K, Mizuno, S, Mizutani, M, Horio, T, Hanamura, I, Espinoza, JL, Matsuo, K, Onizuka, M, Kashiwase, K, Morishima, Y, Fukuda, T, Kodera, Y, Doki, N, Miyamura, K, Mori, TMT & Takami, A 2016, 'Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies', Transplant Immunology, vol. 38, pp. 60-66. https://doi.org/10.1016/j.trim.2016.06.002

Uchino, Kaori ; Mizuno, Shohei ; Mizutani, Motonori ; Horio, Tomohiro ; Hanamura, Ichiro ; Espinoza, J. Luis ; Matsuo, Keitaro ; Onizuka, Makoto ; Kashiwase, Koichi ; Morishima, Yasuo ; Fukuda, Takahiro ; Kodera, Yoshihisa ; Doki, Noriko ; Miyamura, Koichi ; Mori, Takehiko Mori Takehiko ; Takami, Akiyoshi. / Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies. In: Transplant Immunology. 2016 ; Vol. 38. pp. 60-66.

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abstract = "Toll-like receptor 1 (TLR1) genetic variant (rs5743551, − 7202A > G) has been reported to be associated with susceptibility to various infectious diseases. We retrospectively examined the impact of TLR1 variation on transplant outcomes in a cohort of 320 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. A multivariate analysis showed that the G/G genotype in the recipients and the donors was associated with a significantly lower 3-year transplant-related mortality (TRM). The recipient G/G genotype also resulted in a better 3-year progression-free survival. This study suggests that the recipient and donor TLR1 G/G genotypes are comparably associated with a reduced risk of death that was not related to relapse. Thus, TLR1 genotyping may be useful for selecting the donor, managing patients in a risk-adapted manner, and creating therapeutic strategies to prevent complications after hematopoietic stem cell transplantation.",

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