TY - JOUR
T1 - Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies
AU - Uchino, Kaori
AU - Mizuno, Shohei
AU - Mizutani, Motonori
AU - Horio, Tomohiro
AU - Hanamura, Ichiro
AU - Espinoza, J. Luis
AU - Matsuo, Keitaro
AU - Onizuka, Makoto
AU - Kashiwase, Koichi
AU - Morishima, Yasuo
AU - Fukuda, Takahiro
AU - Kodera, Yoshihisa
AU - Doki, Noriko
AU - Miyamura, Koichi
AU - Mori, Takehiko Mori Takehiko
AU - Takami, Akiyoshi
N1 - Funding Information:
This study was supported by grants from the Ministry of Education, Culture, Sports and Technology of Japan ( 24591418 ), a Research on Allergic Disease and Immunology (H26-106) in Health and Labor Science Grant from the Ministry of Health, Labour and Welfare of Japan, the SENSHIN Medical Research Foundation (Osaka, Japan), the Aichi Cancer Research Foundation (Nagoya, Japan), and the 24th General Assembly of the Japanese Association of Medical Sciences (Nagoya, Japan). The funders played no role in the study design, data collection and analysis, the decision to publish or the preparation of the manuscript.
Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Toll-like receptor 1 (TLR1) genetic variant (rs5743551, − 7202A > G) has been reported to be associated with susceptibility to various infectious diseases. We retrospectively examined the impact of TLR1 variation on transplant outcomes in a cohort of 320 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. A multivariate analysis showed that the G/G genotype in the recipients and the donors was associated with a significantly lower 3-year transplant-related mortality (TRM). The recipient G/G genotype also resulted in a better 3-year progression-free survival. This study suggests that the recipient and donor TLR1 G/G genotypes are comparably associated with a reduced risk of death that was not related to relapse. Thus, TLR1 genotyping may be useful for selecting the donor, managing patients in a risk-adapted manner, and creating therapeutic strategies to prevent complications after hematopoietic stem cell transplantation.
AB - Toll-like receptor 1 (TLR1) genetic variant (rs5743551, − 7202A > G) has been reported to be associated with susceptibility to various infectious diseases. We retrospectively examined the impact of TLR1 variation on transplant outcomes in a cohort of 320 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. A multivariate analysis showed that the G/G genotype in the recipients and the donors was associated with a significantly lower 3-year transplant-related mortality (TRM). The recipient G/G genotype also resulted in a better 3-year progression-free survival. This study suggests that the recipient and donor TLR1 G/G genotypes are comparably associated with a reduced risk of death that was not related to relapse. Thus, TLR1 genotyping may be useful for selecting the donor, managing patients in a risk-adapted manner, and creating therapeutic strategies to prevent complications after hematopoietic stem cell transplantation.
KW - Bone marrow transplantation
KW - Single nucleotide variation
KW - TLR1
KW - Unrelated donor
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U2 - 10.1016/j.trim.2016.06.002
DO - 10.1016/j.trim.2016.06.002
M3 - Article
C2 - 27369862
AN - SCOPUS:84987602230
VL - 38
SP - 60
EP - 66
JO - Transplant Immunology
JF - Transplant Immunology
SN - 0966-3274
ER -
