Topological Design of Star Glycopolymers for Controlling the Interaction with the Influenza Virus

Masanori Nagao, Teruhiko Matsubara, Yu Hoshino, Toshinori Sato, Yoshiko Miura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The precise design of synthetic polymer ligands using controlled polymerization techniques provides an advantage for the field of nanoscience. We report the topological design of glyco-ligands based on synthetic polymers for targeting hemagglutinin (HA, lectin on the influenza virus). To achieve precise arrangement of the glycounits toward the sugar-binding pockets of HA, triarm star glycopolymers were synthesized. The interaction of the star glycopolymers with HA was found to depend on the length of the polymer arms and was maximized when the hydrodynamic diameter of the star glycopolymer was comparable to the distance between the sugar-binding pockets of HA. Following the formula of multivalent interaction, the number of binding sites in the interaction of the glycopolymers with HA was estimated as 1.8-2.7. Considering one HA molecule has three sugar-binding pockets, these values were reasonable. The binding mode of synthetic glycopolymer-ligands toward lectins could be tuned using controlled radical polymerization techniques.

Original languageEnglish
Pages (from-to)1192-1198
Number of pages7
JournalBioconjugate Chemistry
Volume30
Issue number4
DOIs
Publication statusPublished - 2019 Apr 17

Fingerprint

Orthomyxoviridae
Viruses
Sugars
Stars
Polymers
Ligands
Lectins
Polymerization
Nanoscience
Hemagglutinins
Binding sites
Hydrodynamics
Free radical polymerization
Binding Sites
Molecules

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

Cite this

Topological Design of Star Glycopolymers for Controlling the Interaction with the Influenza Virus. / Nagao, Masanori; Matsubara, Teruhiko; Hoshino, Yu; Sato, Toshinori; Miura, Yoshiko.

In: Bioconjugate Chemistry, Vol. 30, No. 4, 17.04.2019, p. 1192-1198.

Research output: Contribution to journalArticle

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