Total energy expenditure is comparable between patients with and without diabetes mellitus: Clinical Evaluation of Energy Requirements in Patients with Diabetes Mellitus (CLEVER-DM) Study

Katsutaro Morino, Keiko Kondo, Shigeho Tanaka, Yuki Nishida, Satoshi Nakae, Yosuke Yamada, Satoshi Ugi, Keiko Fuse, Itsuko Miyazawa, Akiko Ohi, Kaori Nishida, Mika Kurihara, Masaya Sasaki, Naoyuki Ebine, Satoshi Sasaki, Fuminori Katsukawa, Hiroshi Maegawa

Research output: Contribution to journalArticle

Abstract

Objective Assessment of total energy expenditure (TEE) is essential for appropriate recommendations regarding dietary intake and physical activity in patients with and without diabetes mellitus (DM). However, few reports have focused on TEE in patients with DM, particularly in Asian countries. Therefore, we evaluated TEE in Japanese patients with DM using the doubly labeled water (DLW) method and physical activity level (PAL). Research design and methods In this cross-sectional observational study, we evaluated 52 patients with type 2 DM and 15 patients without DM. Free-living TEE was measured over 12-16 days by the DLW method, and PAL was calculated as TEE divided by the basal metabolic rate (BMR) as assessed by indirect calorimetry. The equivalence margin was defined as 5 kcal/kg/day. Results The numbers of patients with DM treated with insulin, oral antidiabetic drugs, and diet were 18 (34.6%), 20 (38.5%), and 14 (26.9%), respectively. The mean±SD level of glycated hemoglobin was 6.9%±0.8% and 5.5%±0.3% in the DM and non-DM group, respectively (p<0.001). The mean body mass index was 23.3±3.0 and 22.7±2.1 kg/m 2 in the DM and non-DM group, respectively. The mean TEE per kilogram body weight adjusted for sex and age was 36.5 kcal/kg/day and 37.5 kcal/kg/day in the DM and non-DM group, respectively, with no significant difference (mean difference,-1.0 kcal/kg/day; 95% CI-4.2 to 2.3 kcal/kg/day). The BMR tended to be higher in the DM than in the non-DM group (mean difference, 33 kcal/day; 95% CI,-15 to 80 kcal/day). The mean PAL adjusted for sex and age was 1.71 and 1.81 in the DM and non-DM group, respectively, without a significant difference (mean difference,-0.10; 95% CI-0.21 to 0.01). Conclusion TEE was comparable between Japanese patients with and without DM. Trial registration number UMIN000023051.

Original languageEnglish
Article numbere000648
JournalBMJ Open Diabetes Research and Care
Volume7
Issue number1
DOIs
Publication statusPublished - 2019 Mar 1

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Energy Metabolism
Diabetes Mellitus
Exercise
Basal Metabolism
Indirect Calorimetry
Water
Glycosylated Hemoglobin A
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Observational Studies
Body Mass Index
Research Design
Cross-Sectional Studies
Body Weight
Insulin
Diet

Keywords

  • energy expesnditure
  • physical activity
  • type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Total energy expenditure is comparable between patients with and without diabetes mellitus : Clinical Evaluation of Energy Requirements in Patients with Diabetes Mellitus (CLEVER-DM) Study. / Morino, Katsutaro; Kondo, Keiko; Tanaka, Shigeho; Nishida, Yuki; Nakae, Satoshi; Yamada, Yosuke; Ugi, Satoshi; Fuse, Keiko; Miyazawa, Itsuko; Ohi, Akiko; Nishida, Kaori; Kurihara, Mika; Sasaki, Masaya; Ebine, Naoyuki; Sasaki, Satoshi; Katsukawa, Fuminori; Maegawa, Hiroshi.

In: BMJ Open Diabetes Research and Care, Vol. 7, No. 1, e000648, 01.03.2019.

Research output: Contribution to journalArticle

Morino, K, Kondo, K, Tanaka, S, Nishida, Y, Nakae, S, Yamada, Y, Ugi, S, Fuse, K, Miyazawa, I, Ohi, A, Nishida, K, Kurihara, M, Sasaki, M, Ebine, N, Sasaki, S, Katsukawa, F & Maegawa, H 2019, 'Total energy expenditure is comparable between patients with and without diabetes mellitus: Clinical Evaluation of Energy Requirements in Patients with Diabetes Mellitus (CLEVER-DM) Study', BMJ Open Diabetes Research and Care, vol. 7, no. 1, e000648. https://doi.org/10.1136/bmjdrc-2019-000648
Morino, Katsutaro ; Kondo, Keiko ; Tanaka, Shigeho ; Nishida, Yuki ; Nakae, Satoshi ; Yamada, Yosuke ; Ugi, Satoshi ; Fuse, Keiko ; Miyazawa, Itsuko ; Ohi, Akiko ; Nishida, Kaori ; Kurihara, Mika ; Sasaki, Masaya ; Ebine, Naoyuki ; Sasaki, Satoshi ; Katsukawa, Fuminori ; Maegawa, Hiroshi. / Total energy expenditure is comparable between patients with and without diabetes mellitus : Clinical Evaluation of Energy Requirements in Patients with Diabetes Mellitus (CLEVER-DM) Study. In: BMJ Open Diabetes Research and Care. 2019 ; Vol. 7, No. 1.
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abstract = "Objective Assessment of total energy expenditure (TEE) is essential for appropriate recommendations regarding dietary intake and physical activity in patients with and without diabetes mellitus (DM). However, few reports have focused on TEE in patients with DM, particularly in Asian countries. Therefore, we evaluated TEE in Japanese patients with DM using the doubly labeled water (DLW) method and physical activity level (PAL). Research design and methods In this cross-sectional observational study, we evaluated 52 patients with type 2 DM and 15 patients without DM. Free-living TEE was measured over 12-16 days by the DLW method, and PAL was calculated as TEE divided by the basal metabolic rate (BMR) as assessed by indirect calorimetry. The equivalence margin was defined as 5 kcal/kg/day. Results The numbers of patients with DM treated with insulin, oral antidiabetic drugs, and diet were 18 (34.6{\%}), 20 (38.5{\%}), and 14 (26.9{\%}), respectively. The mean±SD level of glycated hemoglobin was 6.9{\%}±0.8{\%} and 5.5{\%}±0.3{\%} in the DM and non-DM group, respectively (p<0.001). The mean body mass index was 23.3±3.0 and 22.7±2.1 kg/m 2 in the DM and non-DM group, respectively. The mean TEE per kilogram body weight adjusted for sex and age was 36.5 kcal/kg/day and 37.5 kcal/kg/day in the DM and non-DM group, respectively, with no significant difference (mean difference,-1.0 kcal/kg/day; 95{\%} CI-4.2 to 2.3 kcal/kg/day). The BMR tended to be higher in the DM than in the non-DM group (mean difference, 33 kcal/day; 95{\%} CI,-15 to 80 kcal/day). The mean PAL adjusted for sex and age was 1.71 and 1.81 in the DM and non-DM group, respectively, without a significant difference (mean difference,-0.10; 95{\%} CI-0.21 to 0.01). Conclusion TEE was comparable between Japanese patients with and without DM. Trial registration number UMIN000023051.",
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T1 - Total energy expenditure is comparable between patients with and without diabetes mellitus

T2 - Clinical Evaluation of Energy Requirements in Patients with Diabetes Mellitus (CLEVER-DM) Study

AU - Morino, Katsutaro

AU - Kondo, Keiko

AU - Tanaka, Shigeho

AU - Nishida, Yuki

AU - Nakae, Satoshi

AU - Yamada, Yosuke

AU - Ugi, Satoshi

AU - Fuse, Keiko

AU - Miyazawa, Itsuko

AU - Ohi, Akiko

AU - Nishida, Kaori

AU - Kurihara, Mika

AU - Sasaki, Masaya

AU - Ebine, Naoyuki

AU - Sasaki, Satoshi

AU - Katsukawa, Fuminori

AU - Maegawa, Hiroshi

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Objective Assessment of total energy expenditure (TEE) is essential for appropriate recommendations regarding dietary intake and physical activity in patients with and without diabetes mellitus (DM). However, few reports have focused on TEE in patients with DM, particularly in Asian countries. Therefore, we evaluated TEE in Japanese patients with DM using the doubly labeled water (DLW) method and physical activity level (PAL). Research design and methods In this cross-sectional observational study, we evaluated 52 patients with type 2 DM and 15 patients without DM. Free-living TEE was measured over 12-16 days by the DLW method, and PAL was calculated as TEE divided by the basal metabolic rate (BMR) as assessed by indirect calorimetry. The equivalence margin was defined as 5 kcal/kg/day. Results The numbers of patients with DM treated with insulin, oral antidiabetic drugs, and diet were 18 (34.6%), 20 (38.5%), and 14 (26.9%), respectively. The mean±SD level of glycated hemoglobin was 6.9%±0.8% and 5.5%±0.3% in the DM and non-DM group, respectively (p<0.001). The mean body mass index was 23.3±3.0 and 22.7±2.1 kg/m 2 in the DM and non-DM group, respectively. The mean TEE per kilogram body weight adjusted for sex and age was 36.5 kcal/kg/day and 37.5 kcal/kg/day in the DM and non-DM group, respectively, with no significant difference (mean difference,-1.0 kcal/kg/day; 95% CI-4.2 to 2.3 kcal/kg/day). The BMR tended to be higher in the DM than in the non-DM group (mean difference, 33 kcal/day; 95% CI,-15 to 80 kcal/day). The mean PAL adjusted for sex and age was 1.71 and 1.81 in the DM and non-DM group, respectively, without a significant difference (mean difference,-0.10; 95% CI-0.21 to 0.01). Conclusion TEE was comparable between Japanese patients with and without DM. Trial registration number UMIN000023051.

AB - Objective Assessment of total energy expenditure (TEE) is essential for appropriate recommendations regarding dietary intake and physical activity in patients with and without diabetes mellitus (DM). However, few reports have focused on TEE in patients with DM, particularly in Asian countries. Therefore, we evaluated TEE in Japanese patients with DM using the doubly labeled water (DLW) method and physical activity level (PAL). Research design and methods In this cross-sectional observational study, we evaluated 52 patients with type 2 DM and 15 patients without DM. Free-living TEE was measured over 12-16 days by the DLW method, and PAL was calculated as TEE divided by the basal metabolic rate (BMR) as assessed by indirect calorimetry. The equivalence margin was defined as 5 kcal/kg/day. Results The numbers of patients with DM treated with insulin, oral antidiabetic drugs, and diet were 18 (34.6%), 20 (38.5%), and 14 (26.9%), respectively. The mean±SD level of glycated hemoglobin was 6.9%±0.8% and 5.5%±0.3% in the DM and non-DM group, respectively (p<0.001). The mean body mass index was 23.3±3.0 and 22.7±2.1 kg/m 2 in the DM and non-DM group, respectively. The mean TEE per kilogram body weight adjusted for sex and age was 36.5 kcal/kg/day and 37.5 kcal/kg/day in the DM and non-DM group, respectively, with no significant difference (mean difference,-1.0 kcal/kg/day; 95% CI-4.2 to 2.3 kcal/kg/day). The BMR tended to be higher in the DM than in the non-DM group (mean difference, 33 kcal/day; 95% CI,-15 to 80 kcal/day). The mean PAL adjusted for sex and age was 1.71 and 1.81 in the DM and non-DM group, respectively, without a significant difference (mean difference,-0.10; 95% CI-0.21 to 0.01). Conclusion TEE was comparable between Japanese patients with and without DM. Trial registration number UMIN000023051.

KW - energy expesnditure

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