The highly oxygenated polyketide antibiotics, lactonamycin and lactonamycin Z were synthesized. The BCDEF ring system was constructed by a cycloaddition and a palladium-catalyzed cyclization and a Bischler-Napieralski-type cyclization was used for the formation of the A ring. The glycosylation of the aglycon with the appropriate sugar gave lactonamycin and lactonamycin Z.
- Bischler-Napieralski cyclization
- natural products
- total synthesis
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