Total synthesis and bioactivity of resolvin E2

Seiji Ogawa, Daisuke Urabe, Yoshiyuki Yokokura, Hiroyuki Arai, Makoto Arita, Masayuki Inoue

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Image Presented Resolvin E2 is a potent anti-inflammatory compound, derived from eicosapentaenoic acid. The efficient total synthesis of resolvin E2 by taking advantage of its intrinsic pseudoenantiomeric substructures is reported. The synthetic resolvin E2 proved to be biologically active in blocking neutrophil infiltration and reducing proinflammatory cytokines in the acute peritonitis model.

Original languageEnglish
Pages (from-to)3602-3605
Number of pages4
JournalOrganic Letters
Volume11
Issue number16
DOIs
Publication statusPublished - 2009 Aug 20
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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  • Cite this

    Ogawa, S., Urabe, D., Yokokura, Y., Arai, H., Arita, M., & Inoue, M. (2009). Total synthesis and bioactivity of resolvin E2. Organic Letters, 11(16), 3602-3605. https://doi.org/10.1021/ol901350g