Abstract
The total synthesis of melleumin A (1), a novel cyclic depsipeptide isolated from the myxomycete Physarum melleum, and 3-epi-melleumin A (6) was achieved. Melleumin A-like compounds were also designed and synthesized; analysis of these melleumin A-like compounds showed moderate Wnt signal inhibition. Comparison of the inhibition activity of melleumin B and its three epimers, melleumin A, 3-epi-melleumin A and three melleumin A-like compounds led to further investigation of the structural conformation of the active molecules. The scaffold of melleumin is a potential target in the search for "peptide-like" Wnt signaling inhibitors.
| Original language | English |
|---|---|
| Pages (from-to) | 5285-5293 |
| Number of pages | 9 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 8 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - 2010 Dec 7 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Arai, M. A., Hanazawa, S., Uchino, Y., Li, X., & Ishibashi, M. (2010). Total synthesis and evaluation of Wnt signal inhibition of melleumin A and B, and their derivatives. Organic and Biomolecular Chemistry, 8(23), 5285-5293. https://doi.org/10.1039/c0ob00352b