Total synthesis and stereochemical reassignment of maedamide

Ayano Takayanagi, Arihiro Iwasaki, Kiyotake Suenaga

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

Abstract The first total synthesis of maedamide, an acyclic peptide isolated from a marine cyanobacterial assemblage of Lyngbya sp., was achieved. This synthesis led to reassignment of the allo-d-Ile of maedamide to be l-Ile, which was supported by <sup>1</sup>H and <sup>13</sup>C NMR data.

Original languageEnglish
Article number46482
Pages (from-to)4947-4949
Number of pages3
JournalTetrahedron Letters
Volume56
Issue number34
DOIs
Publication statusPublished - 2015 May 29

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Peptides
Nuclear magnetic resonance
Carbon-13 Magnetic Resonance Spectroscopy
Proton Magnetic Resonance Spectroscopy

Keywords

  • Lyngbya
  • Maedamide
  • Marine cyanobacteria
  • Marine natural products
  • Total synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Total synthesis and stereochemical reassignment of maedamide. / Takayanagi, Ayano; Iwasaki, Arihiro; Suenaga, Kiyotake.

In: Tetrahedron Letters, Vol. 56, No. 34, 46482, 29.05.2015, p. 4947-4949.

Research output: Contribution to journal › Article

Takayanagi, A, Iwasaki, A & Suenaga, K 2015, 'Total synthesis and stereochemical reassignment of maedamide', Tetrahedron Letters, vol. 56, no. 34, 46482, pp. 4947-4949. https://doi.org/10.1016/j.tetlet.2015.06.090
Takayanagi A, Iwasaki A, Suenaga K. Total synthesis and stereochemical reassignment of maedamide. Tetrahedron Letters. 2015 May 29;56(34):4947-4949. 46482. https://doi.org/10.1016/j.tetlet.2015.06.090
Takayanagi, Ayano ; Iwasaki, Arihiro ; Suenaga, Kiyotake. / Total synthesis and stereochemical reassignment of maedamide. In: Tetrahedron Letters. 2015 ; Vol. 56, No. 34. pp. 4947-4949.
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