Total synthesis of (+)-7-deoxypancratistatin and (+)-7-deoxy-trans-dihydronarciclasine

Noritaka Chida; Makoto Jitsuoka; Yoshiyuki Yamamoto; Masami Ohtsuka; Seiichiro Ogawa

doi:10.3987/COM-96-7481

Total synthesis of (+)-7-deoxypancratistatin and (+)-7-deoxy-trans-dihydronarciclasine

Noritaka Chida, Makoto Jitsuoka, Yoshiyuki Yamamoto, Masami Ohtsuka, Seiichiro Ogawa

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

The chiral and stereoselective synthesis of antimitotic phenanthridone alkaloids, (+)-7-deoxypancratistatin (1) and (+)-7-deoxy- trans-dihydronarciclasine (2) is described. Both natural products were synthesized from the common compound (4), which had been prepared from D-glucose and employed for the synthesis of lycoricidine (3).

Original language	English
Pages (from-to)	1385-1390
Number of pages	6
Journal	Heterocycles
Volume	43
Issue number	7
DOIs	https://doi.org/10.3987/COM-96-7481
Publication status	Published - 1996 Jan 1

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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AU - Chida, Noritaka

AU - Jitsuoka, Makoto

AU - Yamamoto, Yoshiyuki

AU - Ohtsuka, Masami

AU - Ogawa, Seiichiro

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Y1 - 1996/1/1

N2 - The chiral and stereoselective synthesis of antimitotic phenanthridone alkaloids, (+)-7-deoxypancratistatin (1) and (+)-7-deoxy- trans-dihydronarciclasine (2) is described. Both natural products were synthesized from the common compound (4), which had been prepared from D-glucose and employed for the synthesis of lycoricidine (3).

AB - The chiral and stereoselective synthesis of antimitotic phenanthridone alkaloids, (+)-7-deoxypancratistatin (1) and (+)-7-deoxy- trans-dihydronarciclasine (2) is described. Both natural products were synthesized from the common compound (4), which had been prepared from D-glucose and employed for the synthesis of lycoricidine (3).

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Total synthesis of (+)-7-deoxypancratistatin and (+)-7-deoxy-trans-dihydronarciclasine

Abstract

ASJC Scopus subject areas

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