Total synthesis of (+)-7-deoxypancratistatin and (+)-7-deoxy-trans-dihydronarciclasine

Noritaka Chida, Makoto Jitsuoka, Yoshiyuki Yamamoto, Masami Ohtsuka, Seiichiro Ogawa

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Abstract

The chiral and stereoselective synthesis of antimitotic phenanthridone alkaloids, (+)-7-deoxypancratistatin (1) and (+)-7-deoxy- trans-dihydronarciclasine (2) is described. Both natural products were synthesized from the common compound (4), which had been prepared from D-glucose and employed for the synthesis of lycoricidine (3).

Original languageEnglish
Pages (from-to)1385-1390
Number of pages6
JournalHeterocycles
Volume43
Issue number7
Publication statusPublished - 1996

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ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Chida, N., Jitsuoka, M., Yamamoto, Y., Ohtsuka, M., & Ogawa, S. (1996). Total synthesis of (+)-7-deoxypancratistatin and (+)-7-deoxy-trans-dihydronarciclasine. Heterocycles, 43(7), 1385-1390.