Total synthesis of A-315675 based on the cascade Overman rearrangement

Takayuki Momose, Naoto Hama, Chiharu Higashino, Hideyuki Sato, Noritaka Chida

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The chiral and stereoselective total synthesis of A-315675 1, an antiinfluenza agent, is described. The vicinal diamino moiety in 1 was stereoselectively constructed by the cascade Overman rearrangement of a vicinal allylic-homoallylic diol derived from d-tartrate.

Original languageEnglish
Pages (from-to)1376-1379
Number of pages4
JournalTetrahedron Letters
Volume49
Issue number8
DOIs
Publication statusPublished - 2008 Feb 18

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tartaric acid

Keywords

  • A-315675
  • Antiinfluenza agent
  • Cascade Overman rearrangement
  • Total synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Total synthesis of A-315675 based on the cascade Overman rearrangement. / Momose, Takayuki; Hama, Naoto; Higashino, Chiharu; Sato, Hideyuki; Chida, Noritaka.

In: Tetrahedron Letters, Vol. 49, No. 8, 18.02.2008, p. 1376-1379.

Research output: Contribution to journalArticle

Momose, Takayuki ; Hama, Naoto ; Higashino, Chiharu ; Sato, Hideyuki ; Chida, Noritaka. / Total synthesis of A-315675 based on the cascade Overman rearrangement. In: Tetrahedron Letters. 2008 ; Vol. 49, No. 8. pp. 1376-1379.
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