Total synthesis of (-)-agelastatin A: The application of a sequential sigmatropic rearrangement

Naoto Hama, Tomoki Matsuda, Takaaki Sato, Noritaka Chida

Research output: Contribution to journalArticle

68 Citations (Scopus)


An enantioselective total synthesis of (-)-agelastatin A from (-)-2,3-O-isopropylidene-D-threitol is described. The sequential Overman/Mislow-Evans rearrangement of the allylic bistrichloroimidate is the key step, which efficiently installed a diaminohydroxy group.

Original languageEnglish
Pages (from-to)2687-2690
Number of pages4
JournalOrganic Letters
Issue number12
Publication statusPublished - 2009 Jun 18


ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this