Total synthesis of (-)-agelastatin A: The application of a sequential sigmatropic rearrangement

Naoto Hama, Tomoki Matsuda, Takaaki Satou, Noritaka Chida

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

An enantioselective total synthesis of (-)-agelastatin A from (-)-2,3-O-isopropylidene-D-threitol is described. The sequential Overman/Mislow-Evans rearrangement of the allylic bistrichloroimidate is the key step, which efficiently installed a diaminohydroxy group.

Original languageEnglish
Pages (from-to)2687-2690
Number of pages4
JournalOrganic Letters
Volume11
Issue number12
DOIs
Publication statusPublished - 2009 Jun 18

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synthesis
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agelastatin A

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Total synthesis of (-)-agelastatin A : The application of a sequential sigmatropic rearrangement. / Hama, Naoto; Matsuda, Tomoki; Satou, Takaaki; Chida, Noritaka.

In: Organic Letters, Vol. 11, No. 12, 18.06.2009, p. 2687-2690.

Research output: Contribution to journalArticle

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