The first total synthesis of the antibiotic (−)-hygromycin A (1) has been achieved by a coupling reaction of the sugar moiety (2) and the cyclitol moiety (3). Both components were synthesized in homochiral forms starting from D-glucose. This synthesis fully confirmed the unique structure of 1, which is much different from other usual aminocyclitol antibiotics.
|Number of pages||8|
|Journal||Journal of Organic Chemistry|
|Publication status||Published - 1991 Apr 1|
ASJC Scopus subject areas
- Organic Chemistry