Total synthesis of antibiotic hygromycin A

Noritaka Chida, Masami Ohtsuka, Keiichi Nakazawa, Seiichiro Ogawa

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

The first total synthesis of the antibiotic (-)-hygromycin A (1) has been achieved by a coupling reaction of the sugar moiety (2) and the cyclitol moiety (3). Both components were synthesized in homochiral forms starting from D-glucose. This synthesis fully confirmed the unique structure of 1, which is much different from other usual aminocyclitol antibiotics.

Original languageEnglish
Pages (from-to)2976-2983
Number of pages8
JournalJournal of Organic Chemistry
Volume56
Issue number9
Publication statusPublished - 1991

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Cyclitols
Anti-Bacterial Agents
Sugars
Glucose
hygromycin A

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Chida, N., Ohtsuka, M., Nakazawa, K., & Ogawa, S. (1991). Total synthesis of antibiotic hygromycin A. Journal of Organic Chemistry, 56(9), 2976-2983.

Total synthesis of antibiotic hygromycin A. / Chida, Noritaka; Ohtsuka, Masami; Nakazawa, Keiichi; Ogawa, Seiichiro.

In: Journal of Organic Chemistry, Vol. 56, No. 9, 1991, p. 2976-2983.

Research output: Contribution to journalArticle

Chida, N, Ohtsuka, M, Nakazawa, K & Ogawa, S 1991, 'Total synthesis of antibiotic hygromycin A', Journal of Organic Chemistry, vol. 56, no. 9, pp. 2976-2983.
Chida N, Ohtsuka M, Nakazawa K, Ogawa S. Total synthesis of antibiotic hygromycin A. Journal of Organic Chemistry. 1991;56(9):2976-2983.
Chida, Noritaka ; Ohtsuka, Masami ; Nakazawa, Keiichi ; Ogawa, Seiichiro. / Total synthesis of antibiotic hygromycin A. In: Journal of Organic Chemistry. 1991 ; Vol. 56, No. 9. pp. 2976-2983.
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