Total Synthesis of Biselyngbyaside

Eisuke Sato, Miho Sato, Yurika Tanabe, Naoya Nakajima, Akifumi Ohkubo, Kiyotake Suenaga

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7 Citations (Scopus)

Abstract

The first total synthesis of biselyngbyaside, an 18-membered macrolide glycoside, was achieved. The glycoside bond was introduced using the Schmidt method before construction of the 18-membered ring due to the instability of the conjugated diene and the β-hydroxy ester moiety. The macrolactone ring was constructed using the Mitsunobu reaction followed by intramolecular the Stille coupling reaction.

Original languageEnglish
Pages (from-to)6770-6777
Number of pages8
JournalJournal of Organic Chemistry
Volume82
Issue number13
DOIs
Publication statusPublished - 2017 Jul 7

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ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Sato, E., Sato, M., Tanabe, Y., Nakajima, N., Ohkubo, A., & Suenaga, K. (2017). Total Synthesis of Biselyngbyaside. Journal of Organic Chemistry, 82(13), 6770-6777. https://doi.org/10.1021/acs.joc.7b00905