@article{e62944411d444854bc1c651f089e41fa,
title = "Total Synthesis of Caldorazole, a Potent Mitochondrial Respiratory Chain Inhibitor without Chiral Centers",
abstract = "Caldorazole (1) is a novel polyketide that was isolated from a marine cyanobacterium in 2022. It is a unique natural product that exhibits potent inhibitory activity against mitochondrial respiratory chain complex I despite having no chiral centers. To establish a method for obtaining caldorazole without relying on biological resources and for constructing a useful synthetic route for studies of its structure-activity relationship, we achieved the first total synthesis of caldorazole using a convergent synthetic route.",
author = "Yuta Miyamoto and Arihiro Iwasaki and Haruka Fujimura and Chihiro Kudo and Naoaki Kurisawa and Osamu Ohno and Kiyotake Suenaga",
note = "Funding Information: This work was supported by JSPS KAKENHI grant 20H02870. We thank Nippon Yttrium Co., Ltd. for their gift of samarium metal for the preparation of the SmI solution and Prof. Taiki Umezawa (Hokkaido Univ.) for the advice. 2 Funding Information: This work was supported by JSPS KAKENHI grant 20H02870. We thank Nippon Yttrium Co., Ltd. for their gift of samarium metal for the preparation of the SmI2 solution and Prof. Taiki Umezawa (Hokkaido Univ.) for the advice. Publisher Copyright: {\textcopyright} 2023 American Chemical Society.",
year = "2023",
month = mar,
day = "3",
doi = "10.1021/acs.joc.2c03007",
language = "English",
volume = "88",
pages = "3208--3216",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "5",
}
