TY - JOUR
T1 - Total Synthesis of Cardiolipins Containing Chiral Cyclopropane Fatty Acids
AU - Inuki, Shinsuke
AU - Ohta, Ippei
AU - Ishibashi, Shunichi
AU - Takamatsu, Masayuki
AU - Fukase, Koichi
AU - Fujimoto, Yukari
N1 - Funding Information:
This research was financially supported by grants from the JSPS KAKENHI (Nos. JP26282211, JP26102732, JP26882036, and JP16K16638), NEXT Program (LR025) from JSPS and CSTP, the Mizutani Foundation for Glycoscience, and the Nagase Science Technology Foundation and Protein Research Foundation.
PY - 2017/8/4
Y1 - 2017/8/4
N2 - Cardiolipin (CL) is a phospholipid located in both the eukaryotic mitochondrial inner membrane and the bacterial cell membrane. Some bacterial CLs are known to contain cyclopropane moieties in their acyl chains. Although the CLs are thought to be involved in the innate immune response, there have been few attempts at chemical synthesis of the CLs, and detailed studies of their biological activities are scarce. Thus, we have developed a synthetic route to CLs containing chiral cyclopropane moieties.
AB - Cardiolipin (CL) is a phospholipid located in both the eukaryotic mitochondrial inner membrane and the bacterial cell membrane. Some bacterial CLs are known to contain cyclopropane moieties in their acyl chains. Although the CLs are thought to be involved in the innate immune response, there have been few attempts at chemical synthesis of the CLs, and detailed studies of their biological activities are scarce. Thus, we have developed a synthetic route to CLs containing chiral cyclopropane moieties.
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U2 - 10.1021/acs.joc.7b00945
DO - 10.1021/acs.joc.7b00945
M3 - Article
C2 - 28682614
AN - SCOPUS:85027075545
VL - 82
SP - 7832
EP - 7838
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
SN - 0022-3263
IS - 15
ER -