Abstract
Cardiolipin (CL) is a phospholipid located in both the eukaryotic mitochondrial inner membrane and the bacterial cell membrane. Some bacterial CLs are known to contain cyclopropane moieties in their acyl chains. Although the CLs are thought to be involved in the innate immune response, there have been few attempts at chemical synthesis of the CLs, and detailed studies of their biological activities are scarce. Thus, we have developed a synthetic route to CLs containing chiral cyclopropane moieties.
| Original language | English |
|---|---|
| Pages (from-to) | 7832-7838 |
| Number of pages | 7 |
| Journal | Journal of Organic Chemistry |
| Volume | 82 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 2017 Aug 4 |
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ASJC Scopus subject areas
- Organic Chemistry
Cite this
Total Synthesis of Cardiolipins Containing Chiral Cyclopropane Fatty Acids. / Inuki, Shinsuke; Ohta, Ippei; Ishibashi, Shunichi; Takamatsu, Masayuki; Fukase, Koichi; Fujimoto, Yukari.
In: Journal of Organic Chemistry, Vol. 82, No. 15, 04.08.2017, p. 7832-7838.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Total Synthesis of Cardiolipins Containing Chiral Cyclopropane Fatty Acids
AU - Inuki, Shinsuke
AU - Ohta, Ippei
AU - Ishibashi, Shunichi
AU - Takamatsu, Masayuki
AU - Fukase, Koichi
AU - Fujimoto, Yukari
PY - 2017/8/4
Y1 - 2017/8/4
N2 - Cardiolipin (CL) is a phospholipid located in both the eukaryotic mitochondrial inner membrane and the bacterial cell membrane. Some bacterial CLs are known to contain cyclopropane moieties in their acyl chains. Although the CLs are thought to be involved in the innate immune response, there have been few attempts at chemical synthesis of the CLs, and detailed studies of their biological activities are scarce. Thus, we have developed a synthetic route to CLs containing chiral cyclopropane moieties.
AB - Cardiolipin (CL) is a phospholipid located in both the eukaryotic mitochondrial inner membrane and the bacterial cell membrane. Some bacterial CLs are known to contain cyclopropane moieties in their acyl chains. Although the CLs are thought to be involved in the innate immune response, there have been few attempts at chemical synthesis of the CLs, and detailed studies of their biological activities are scarce. Thus, we have developed a synthetic route to CLs containing chiral cyclopropane moieties.
UR - http://www.scopus.com/inward/record.url?scp=85027075545&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027075545&partnerID=8YFLogxK
U2 - 10.1021/acs.joc.7b00945
DO - 10.1021/acs.joc.7b00945
M3 - Article
C2 - 28682614
AN - SCOPUS:85027075545
VL - 82
SP - 7832
EP - 7838
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
SN - 0022-3263
IS - 15
ER -