Total synthesis of dapiramicin B

Hiroyuki Ohno, Takashi Terui, Takafumi Kitawaki, Noritaka Chida

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The first total synthesis of dapiramicin B, a nucleoside antibiotic, is described. The characteristic N-glycoside linkage in dapiramicin B was effectively constructed by way of the Pd-catalyzed coupling reaction of a heptopyranosylamine with a bromopyrrolopyrimidine derivative.

Original languageEnglish
Pages (from-to)5747-5750
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number32
DOIs
Publication statusPublished - 2006 Aug 7

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Glycosides
Nucleosides
Anti-Bacterial Agents
Derivatives
dapiramicin B

Keywords

  • Dapiramicin B
  • N-Arylation
  • Nucleoside antibiotic
  • Pd-Catalyzed
  • Total synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Total synthesis of dapiramicin B. / Ohno, Hiroyuki; Terui, Takashi; Kitawaki, Takafumi; Chida, Noritaka.

In: Tetrahedron Letters, Vol. 47, No. 32, 07.08.2006, p. 5747-5750.

Research output: Contribution to journalArticle

Ohno, H, Terui, T, Kitawaki, T & Chida, N 2006, 'Total synthesis of dapiramicin B', Tetrahedron Letters, vol. 47, no. 32, pp. 5747-5750. https://doi.org/10.1016/j.tetlet.2006.06.001
Ohno, Hiroyuki ; Terui, Takashi ; Kitawaki, Takafumi ; Chida, Noritaka. / Total synthesis of dapiramicin B. In: Tetrahedron Letters. 2006 ; Vol. 47, No. 32. pp. 5747-5750.
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